Olfen Retard (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Retard, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral administration. It is classified as an analgesic, anti‑inflammatory and antirheumatic agent and is used to relieve pain and reduce inflammation in adult patients with musculoskeletal disorders such as osteoarthritis and rheumatoid arthritis.

GNH USA supplies Olfen Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare facilities worldwide.

Olfen Retard (diclofenac sodium) is indicated for conditions involving pain and inflammation within the musculoskeletal system.

- Osteoarthritis: reduces joint pain and improves mobility. - Rheumatoid arthritis: decreases inflammation and joint swelling. - Acute pain: provides relief from moderate to severe pain such as postoperative or injury‑related pain.

Like other NSAIDs, diclofenac sodium may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort or dyspepsia. - Nausea or vomiting. - Headache. - Dizziness. - Mild skin rash. - Elevated blood pressure.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Significant liver enzyme elevation or hepatitis. - Renal impairment or failure. - Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome). - Cardiovascular events such as myocardial infarction or stroke. - Blood dyscrasias including agranulocytosis.

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

- Gastrointestinal risk: assess history of ulcers or bleeding before use. - Cardiovascular caution: avoid in patients with established heart disease or high thrombotic risk. - Renal function: monitor kidney function, especially in dehydrated or elderly patients. - Hepatic monitoring: check liver enzymes periodically during prolonged therapy. - Pregnancy and lactation: contraindicated in late pregnancy; use only if benefits outweigh risks. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Diclofenac sodium can interact with several drug classes, requiring careful assessment.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - SSRIs or SNRIs: heightened risk of bleeding.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may enhance renal adverse effects. - Methotrexate: potential for increased toxicity.