Olfen (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Olfen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It relieves mild to moderate pain and reduces inflammation in conditions such as osteoarthritis, rheumatoid arthritis and musculoskeletal injuries.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution. Its network ensures timely delivery to diverse healthcare settings across continents.

Diclofenac is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

- Osteoarthritis: reduces joint pain and improves mobility - Rheumatoid arthritis: decreases inflammation and joint swelling - Musculoskeletal pain: alleviates acute and chronic pain from strains or sprains

Diclofenac may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain - Headache: mild to moderate intensity - Dizziness: transient episodes - Skin rash: mild erythema or itching

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: potentially life‑threatening - Renal impairment: reduced kidney function or acute failure - Hepatotoxicity: elevated liver enzymes or hepatitis - Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome

When using diclofenac, certain precautions should be observed to minimize risks. - Assess renal function: avoid use in severe kidney disease - Monitor hepatic enzymes: caution in liver impairment - Avoid in active peptic ulcer disease: increased bleeding risk - Use cautiously with anticoagulants: heightened hemorrhage potential - Limit duration in elderly: higher susceptibility to adverse effects - Store at ambient temperature: keep in original container, protect from moisture and light

Diclofenac can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk - Selective COX‑2 inhibitors: additive cardiovascular toxicity - Lithium: increased serum levels - Methotrexate: reduced renal clearance leading to toxicity

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect - Diuretics: enhanced renal impairment - Corticosteroids: increased gastrointestinal ulcer risk