Olfen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is employed to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis and acute musculoskeletal injuries in adults.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is an NSAID that acts on inflammatory pathways to reduce pain and swelling in several musculoskeletal conditions. - Osteoarthritis: helps relieve joint pain and improves functional movement. - Rheumatoid arthritis: reduces joint inflammation and stiffness. - Acute musculoskeletal injury: eases pain and inflammation associated with sprains, strains and soft‑tissue trauma. - Post‑operative pain: provides analgesia after minor surgical procedures. - Ankylosing spondylitis: diminishes spinal pain and stiffness.

Adverse reactions to diclofenac sodium can range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash or mild itching. - Elevated liver enzymes detected in routine tests.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury or jaundice. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions including Stevens‑Johnson syndrome.

When using Olfen, consider the following safety measures: - Cardiovascular risk: assess patient history of heart disease before initiating therapy. - Gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding. - Renal function: monitor kidney parameters in patients with pre‑existing renal impairment. - Hepatic function: periodic liver‑function testing is advisable. - Drug interactions: review concomitant medications for potential NSAID interactions. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Diclofenac sodium may interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency. - Lithium: potential for increased lithium levels and toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal perfusion and function. - Diuretics: risk of electrolyte imbalance and renal impairment. - Methotrexate: possible increase in methotrexate toxicity.