Olfen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is employed to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis and acute musculoskeletal injuries.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olfen is a non‑steroidal anti‑inflammatory drug that acts on inflammatory pathways to reduce pain and swelling. - Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: decreases joint inflammation and stiffness. - Acute musculoskeletal pain: provides rapid relief of pain and inflammation following injury or overuse.

Adverse reactions to diclofenac may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient episodes of light‑headedness. - Skin rash: mild erythema or itching. - Elevated liver enzymes: mild, asymptomatic increases in laboratory tests.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury or hepatitis. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions such as Stevens‑Johnson syndrome.

When prescribing Olfen, clinicians should consider several safety aspects. - Cardiovascular risk: assess patient history of heart disease before use. - Gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding. - Renal function: monitor kidney parameters in patients with existing renal impairment. - Hepatic function: check liver enzymes periodically during long‑term therapy. - Drug interactions: review concomitant medications for potential NSAID interactions. - Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture.

Diclofenac may interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - Anticoagulants: increased risk of serious bleeding.\n- Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk. - Lithium: diclofenac can raise serum lithium levels, risking toxicity. - Methotrexate: may increase methotrexate toxicity. - ACE inhibitors/ARBs: can reduce renal perfusion and function.

Moderate Interactions (Monitor Closely): - Diuretics: may potentiate renal effects. - Corticosteroids: additive gastrointestinal irritation. - Beta‑blockers: possible reduction in antihypertensive effect. - Proton‑pump inhibitors: may mask GI symptoms without preventing ulceration. - Alcohol: enhances gastrointestinal toxicity.