Olfen (Diclofenac Sodium)

Diclofenac, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a tablet for oral use. It is employed to relieve pain and reduce inflammation in musculoskeletal and other inflammatory conditions.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olfen (diclofenac) is an NSAID that acts on inflammatory pathways to manage pain and swelling. - Rheumatoid arthritis: reduces joint pain, swelling and stiffness. - Osteoarthritis: alleviates chronic joint discomfort and improves mobility. - Ankylosing spondylitis: diminishes spinal inflammation and pain. - Acute musculoskeletal pain: provides rapid relief of injury‑related pain. - Post‑operative pain: helps control pain after surgical procedures.

Adverse reactions to Olfen can vary from mild to severe.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, abdominal pain. - Headache or dizziness. - Skin rash or pruritus. - Elevated liver enzymes. - Fluid retention or mild edema.

Serious or Rare Side Effects: - Gastrointestinal bleeding or perforation. - Cardiovascular events such as myocardial infarction or stroke. - Severe liver injury or hepatitis. - Acute renal failure or worsening of chronic kidney disease. - Stevens‑Johnson syndrome, toxic epidermal necrolysis, or other severe skin reactions. - Anaphylactic or severe hypersensitivity reactions.

Before initiating Olfen, clinicians should evaluate individual risk factors and monitor therapy. - Gastro‑intestinal risk: assess history of ulcers or bleeding before use. - Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Renal function: monitor creatinine in patients with pre‑existing kidney disease. - Hepatic function: check liver enzymes periodically, especially with prolonged therapy. - Pregnancy: contraindicated in the third trimester; use only if benefits outweigh risks. - Hypersensitivity: discontinue if signs of severe allergic reaction appear. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Olfen may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Lithium: elevated lithium serum levels. - Methotrexate: reduced clearance, risk of toxicity. - Cyclosporine: enhanced nephrotoxicity.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: risk of electrolyte imbalance and renal impairment. - SSRIs or SNRIs: additive bleeding risk. - Beta‑blockers: may mask tachycardia from blood loss. - Corticosteroids: increased gastrointestinal ulceration risk.