Olfen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis and acute musculoskeletal injuries in adults.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olfen is an NSAID that acts on inflammatory pathways to reduce pain and swelling. - Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: decreases joint inflammation and stiffness. - Acute musculoskeletal pain: provides rapid relief of pain and inflammation following injury. - Ankylosing spondylitis: reduces spinal pain and stiffness. - Post‑operative pain: helps control pain after surgical procedures.

Adverse reactions to diclofenac may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient episodes of light‑headedness. - Skin rash: erythematous or maculopapular eruptions. - Elevated liver enzymes: mild, transient increases in hepatic tests.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury or hepatitis. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Stevens‑Johnson syndrome or toxic epidermal necrolysis.

When prescribing Olfen, clinicians should consider patient‑specific risk factors and monitor for adverse events. - Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Gastrointestinal risk: use with caution in those with a history of ulcers or bleeding. - Renal function: assess baseline kidney function and adjust use in chronic kidney disease. - Hepatic function: monitor liver enzymes in patients with liver disease. - Concomitant NSAIDs or anticoagulants: increase bleeding risk; evaluate necessity. - Store below 25°C: keep in the original packaging, protect from moisture and heat.

Diclofenac may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding risk. - Lithium: diclofenac can raise serum lithium levels, risking toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients. - Diuretics: potential for reduced kidney function when combined. - Methotrexate: diclofenac can decrease clearance, raising methotrexate toxicity.