Olfen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug presented as a 50 mg tablet for oral use. It is indicated for the relief of pain and inflammation in musculoskeletal conditions, osteoarthritis and rheumatoid arthritis in adults.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is a NSAID that reduces inflammation and pain in several musculoskeletal and joint disorders. - Osteoarthritis: helps relieve joint pain and improve mobility. - Rheumatoid arthritis: decreases inflammation and joint swelling. - Acute musculoskeletal pain: provides short‑term pain relief after injury or strain. - Ankylosing spondylitis: reduces spinal pain and stiffness. - Post‑operative pain: assists in managing pain following minor surgical procedures.

Adverse reactions to diclofenac may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient episodes of light‑headedness. - Skin rash: mild erythema or itching. - Elevated liver enzymes: mild, reversible changes in liver function tests.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury or hepatitis. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions such as Stevens‑Johnson syndrome.

When prescribing diclofenac, clinicians should consider patient‑specific risk factors and monitor for adverse events. - Cardiovascular risk: assess history of heart disease before use. - Gastro‑intestinal risk: avoid in patients with active ulcers or a history of GI bleeding. - Renal function: monitor kidney parameters in patients with existing renal impairment. - Hepatic function: check liver enzymes periodically, especially in long‑term therapy. - Concomitant NSAIDs: avoid combining with other NSAIDs or aspirin to reduce bleeding risk. - Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Diclofenac can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency. - ACE inhibitors or ARBs: may reduce renal protective effects and increase kidney injury risk.

Moderate Interaction (Monitor Closely): - Diuretics: may potentiate renal function changes. - Lithium: can increase serum lithium levels. - Methotrexate: reduced clearance may raise toxicity risk.