Olfen (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Olfen, is a nonsteroidal anti-inflammatory drug presented as a pharmaceutical preparation for buccal, cutaneous, dental and intradermal use. It reduces inflammation and pain in a range of musculoskeletal and dental conditions for adult patients. GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium is an NSAID that acts on inflammatory pathways to relieve pain and swelling. - Pain relief: Provides analgesic effect in acute and chronic pain conditions. - Inflammation reduction: Decreases swelling and redness in inflamed tissues. - Musculoskeletal disorders: Alleviates symptoms of osteoarthritis, rheumatoid arthritis and soft‑tissue injuries. - Dental pain: Controls postoperative and dental procedure‑related discomfort.

Adverse reactions may occur with diclofenac use and are categorized by frequency.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus.

Serious or Rare Side Effects: - Hepatic toxicity: elevated liver enzymes or hepatitis. - Renal impairment: reduced kidney function or acute kidney injury. - Severe allergic reactions: anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Gastrointestinal ulceration or bleeding, and increased cardiovascular risk.

Before initiating therapy, consider patient‑specific factors and safety measures. - Assess renal function: use caution in patients with impaired kidney function. - Evaluate hepatic status: avoid in severe liver disease. - Review cardiovascular risk: limit use in patients with known heart disease or stroke history. - Avoid concurrent NSAIDs or anticoagulants unless medically justified. - Store at room temperature: keep in the original container, protect from moisture and light.

Diclofenac may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or corticosteroids: heightened gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: possible reduction in renal function. - Lithium: increased serum lithium levels. - Methotrexate: reduced clearance leading to toxicity.