Olfen (Diclofenac Diethylamine)

Diclofenac diethylamine, the active ingredient in Olfen, is a non‑steroidal anti‑inflammatory drug presented as a topical gel for dermal use. It relieves pain and inflammation associated with musculoskeletal conditions such as sprains, strains and osteoarthritis. GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Olfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olfen contains diclofenac diethylamine, a non‑steroidal anti‑inflammatory that acts on prostaglandin pathways to reduce inflammation and pain.

- Musculoskeletal pain: provides topical analgesia for sprains, strains and minor sports injuries. - Osteoarthritis of superficial joints: reduces pain and improves joint function in knee or hand OA. - Acute soft‑tissue inflammation: diminishes swelling and discomfort in tendinitis or bursitis.

Olfen may cause local and systemic adverse reactions.

Common Side Effects: - Skin irritation: redness, itching or burning at the application site. - Dryness or peeling of the skin. - Pruritus. - Mild headache. - Localized rash.

Serious or Rare Side Effects: - Severe allergic reaction: angio‑edema, swelling of the face or throat. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Liver enzyme elevation. - Gastrointestinal ulceration or bleeding (systemic exposure). - Cardiovascular events such as hypertension or thrombotic episodes.

When using Olfen, consider the following safety measures:

- Avoid application on broken or infected skin: may increase systemic absorption. - Do not use with other topical NSAIDs: risk of additive irritation. - Limit use to the recommended surface area: excessive area raises systemic exposure. - Monitor for signs of gastrointestinal discomfort or cardiovascular changes. - Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Olfen can interact with several systemic medications, especially when absorbed in larger amounts.

Major Interactions (Avoid): - Oral anticoagulants (e.g., warfarin): increased risk of bleeding. - Systemic NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Lithium: diclofenac may raise serum lithium levels.

Moderate Interactions (Monitor Closely): - ACE inhibitors, ARBs: may reduce renal function when combined with NSAIDs. - Diuretics: heightened risk of renal impairment. - Methotrexate: potential increase in methotrexate toxicity.