Olfen Depotabs (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Olfen Depotabs, is a nonsteroidal anti-inflammatory drug (NSAID) presented as oral tablets for oral use. It is used to relieve pain and reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis and acute musculoskeletal pain. GNH USA supplies Olfen Depotabs as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium is an NSAID indicated for several painful and inflammatory conditions. - Osteoarthritis: reduces joint pain and improves mobility. - Rheumatoid arthritis: alleviates joint inflammation and stiffness. - Acute musculoskeletal pain: provides rapid pain relief after injury or strain. - Post‑operative pain: helps control pain following surgical procedures. - Ankylosing spondylitis: diminishes spinal inflammation and discomfort.

Diclofenac may cause a range of adverse reactions.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching. - Elevated liver enzymes detected in laboratory tests.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe hepatic injury or jaundice. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe hypersensitivity reactions including Stevens‑Johnson syndrome.

When using Diclofenac, certain precautions should be observed. - Cardiovascular risk: avoid in patients with recent myocardial infarction or uncontrolled hypertension. - Gastrointestinal safety: use with caution in individuals with a history of ulcers or bleeding. - Renal function: monitor kidney parameters in patients with existing renal disease. - Hepatic health: assess liver function before and during therapy. - Pregnancy and lactation: consult a healthcare professional before use. - Store below 25°C: keep in the original pack, protect from moisture.

Diclofenac can interact with several drug classes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may enhance nephrotoxic potential. - Methotrexate: increased methotrexate toxicity at high doses.