Olfen Depocaps (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Depocaps, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a topical gel for dermal use. It is used to relieve pain and inflammation associated with musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis and soft‑tissue injuries in adults.

GNH USA supplies Olfen Depocaps as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Olfen Depocaps is an NSAID that reduces inflammation and pain in several musculoskeletal disorders.

- Osteoarthritis: helps relieve joint pain and improves functional movement. - Rheumatoid arthritis: decreases joint inflammation and swelling. - Acute musculoskeletal injury: alleviates pain and reduces local inflammation. - Post‑operative pain: provides short‑term pain control after minor surgical procedures. - Ankylosing spondylitis: reduces spinal pain and stiffness.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient light‑headedness. - Skin irritation: redness or itching at the application site. - Elevated liver enzymes: mild, asymptomatic changes in blood tests.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Hepatotoxicity: marked elevation of liver enzymes or hepatitis. - Renal impairment: acute kidney injury or worsening of chronic kidney disease. - Anaphylaxis: sudden onset of hives, swelling and respiratory distress.

Olfen Depocaps should be used only after evaluating the patient’s medical history and current medication profile.

- Cardiovascular risk: avoid in patients with uncontrolled hypertension or recent myocardial infarction. - Gastrointestinal history: use cautiously in individuals with a history of ulcers or bleeding. - Renal function: monitor kidney function in patients with chronic kidney disease. - Hepatic function: assess liver enzymes before long‑term use. - Pregnancy and lactation: contraindicated in the third trimester and not recommended while breastfeeding. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Diclofenac may interact with several drug classes, requiring careful review before co‑administration.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive toxicity to the gastrointestinal tract and kidneys. - Lithium: diclofenac can raise serum lithium levels, risking toxicity. - Methotrexate: may reduce renal clearance and increase methotrexate toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may diminish antihypertensive effect and affect renal function. - Diuretics: increased risk of renal impairment. - Corticosteroids: higher chance of gastrointestinal ulceration. - Beta‑blockers: possible reduction in antihypertensive efficacy. - Oral hypoglycemics: may potentiate hypoglycaemic effect.