Olfen Depocaps (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen Depocaps, is a non‑steroidal anti‑inflammatory drug presented as a capsule for oral use. It is used to relieve pain and inflammation associated with musculoskeletal disorders and other inflammatory conditions. GNH USA supplies Olfen Depocaps as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions. - Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: reduces joint swelling and pain. - Ankylosing spondylitis: eases spinal stiffness and discomfort. - Acute musculoskeletal pain: provides rapid relief after injury or strain. - Dysmenorrhea: lessens menstrual cramps and associated pain.

Adverse reactions to diclofenac can range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort. - Headache or dizziness. - Skin rash or pruritus. - Elevated liver enzymes. - Mild renal function changes.

Serious or Rare Side Effects: - Gastrointestinal bleeding or perforation. - Severe hepatic injury or hepatitis. - Acute renal failure or significant creatinine rise. - Cardiovascular events such as myocardial infarction or stroke. - Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Diclofenac should be used with caution in patients with certain medical conditions and concomitant therapies. - Cardiovascular risk: avoid long‑term use in patients with established heart disease. - Gastrointestinal safety: assess history of ulcers or bleeding before prescribing. - Renal function: monitor kidney parameters in patients with chronic kidney disease. - Hepatic monitoring: check liver enzymes periodically, especially in patients with liver disease. - Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Diclofenac can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal impairment. - Lithium: elevated lithium levels leading to toxicity. - Methotrexate: reduced clearance and potential toxicity.

Moderate Interactions (Monitor Closely): - Diuretics: possible decrease in renal perfusion. - Corticosteroids: additive risk of gastrointestinal ulceration. - SSRIs or SNRIs: modest increase in bleeding tendency. - Beta‑blockers: may blunt antihypertensive response. - Cyclosporine: increased nephrotoxicity risk.