Olfen 50 (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Olfen 50, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a 50 mg tablet for oral use. It is commonly prescribed to relieve pain and inflammation in musculoskeletal conditions and other inflammatory disorders.

GNH USA supplies Olfen 50 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory conditions. - Osteoarthritis: alleviates joint pain and improves mobility. - Rheumatoid arthritis: decreases joint inflammation and swelling. - Ankylosing spondylitis: reduces spinal pain and stiffness. - Acute musculoskeletal sprains and strains: provides short‑term pain relief. - Post‑operative pain: helps manage pain after minor surgical procedures.

Adverse reactions to diclofenac sodium can range from mild to severe and may affect multiple organ systems.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, abdominal pain. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash or mild itching. - Elevated liver enzymes.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe liver injury or hepatitis. - Renal impairment or acute kidney injury. - Cardiovascular events such as myocardial infarction or stroke. - Severe skin reactions including Stevens‑Johnson syndrome.

When using diclofenac sodium, several safety considerations should be observed: - Assess renal function: evaluate baseline kidney health before initiating therapy. - Monitor hepatic function: periodic liver‑function tests are recommended. - Evaluate cardiovascular risk: use cautiously in patients with known heart disease. - Avoid concurrent NSAIDs: increase risk of gastrointestinal complications. - Use the lowest effective dose for the shortest duration needed. - Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Diclofenac sodium can interact with a variety of medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding risk. - ACE inhibitors or ARBs: may reduce renal perfusion and function.

Moderate Interactions (Monitor Closely): - Lithium: NSAIDs can raise lithium serum levels. - Methotrexate: reduced clearance may increase toxicity. - Corticosteroids: combined use raises ulcer risk.