Ogast (Lansoprazole)

Lansoprazole, the active ingredient in Ogast, is a proton pump inhibitor presented as a 20 mg tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease and Helicobacter pylori infection in adults.

GNH USA supplies Ogast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lansoprazole acts on the gastric proton pump to decrease acid production, making it useful for several acid‑related disorders. - Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal erosion. - Erosive esophagitis: accelerates mucosal healing and reduces recurrence. - Peptic ulcer disease: supports ulcer healing and prevents recurrence. - Helicobacter pylori eradication regimens: enhances the effectiveness of antibiotic combinations.

Lansoprazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache: mild to moderate intensity. - Diarrhoea: transient loose stools. - Nausea: occasional upset stomach. - Abdominal pain: mild discomfort. - Flatulence: increased gas. - Constipation: reduced bowel movements.

Serious or Rare Side Effects: - Clostridioides difficile infection: severe colitis. - Severe allergic reactions: rash, angioedema, anaphylaxis. - Hepatic injury: elevated liver enzymes, jaundice. - Stevens‑Johnson syndrome/toxic epidermal necrolysis: severe skin reactions. - Hypomagnesemia: low serum magnesium with prolonged use. - Bone fracture risk: increased incidence with long‑term therapy.

When prescribing Lansoprazole, consider the following precautions. - Renal function assessment: adjust use in severe renal impairment. - Long‑term therapy review: limit duration unless clinically indicated. - Magnesium monitoring: check levels during extended treatment. - Hepatic impairment: use with caution in moderate liver disease. - Elderly patients: monitor for increased susceptibility to adverse effects. - Store at below 25°C: keep in the original pack, protect from moisture.

Lansoprazole may interact with several medications, affecting their efficacy or safety.

Major Interactions (Avoid): - Clopidogrel: reduced antiplatelet activity. - Atorvastatin: increased plasma concentration, risk of myopathy. - Methotrexate: heightened toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely): - Warfarin: variable INR, monitor coagulation. - Digoxin: increased serum levels, watch for toxicity. - Diazepam: enhanced absorption, may increase sedation.