Oftaquix (Levofloxacin Hemihydrate)

Levofloxacin Hemihydrate, the active ingredient in Oftaquix, is a fluoroquinolone antibiotic presented as a solid dosage form for oral use. It treats bacterial infections in adults and children when prescribed by a healthcare professional.

GNH USA supplies Oftaquix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levofloxacin is a broad‑spectrum antibacterial agent used in several infection pathways.

- Community‑acquired bacterial pneumonia: helps eradicate the causative organisms and improve respiratory symptoms. - Acute bacterial sinusitis: reduces sinus inflammation and clears the infection. - Uncomplicated urinary tract infection: eliminates the uropathogens responsible for urinary symptoms. - Skin and soft‑tissue infections: controls bacterial proliferation in cutaneous lesions. - Chronic bronchitis exacerbations: assists in resolving bacterial flare‑ups in chronic lung disease.

Levofloxacin may cause a range of adverse reactions, most of which are mild to moderate and resolve after therapy ends.

Common Side Effects: - Nausea: mild stomach upset that may occur during treatment. - Diarrhea: loose stools that are usually self‑limiting. - Headache: transient head discomfort. - Dizziness: occasional light‑headed sensation. - Photosensitivity: increased skin sensitivity to sunlight. - Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects: - Tendon rupture: sudden tendon pain or rupture, especially in the Achilles. - QT interval prolongation: heart rhythm changes detectable on ECG. - Severe allergic reactions: rash, itching, swelling, or difficulty breathing. - Peripheral neuropathy: numbness or tingling in extremities. - Clostridioides difficile infection: severe diarrhea due to bacterial overgrowth. - Liver enzyme elevation: abnormal liver function test results.

Levofloxacin should be used with caution in specific clinical situations and patient populations.

- Renal impairment: dose adjustment may be required based on kidney function. - History of tendon disorders: avoid use if previous tendon inflammation or rupture occurred. - Cardiac arrhythmias: monitor patients with known QT prolongation risk. - Seizure disorders: use cautiously in patients with a history of seizures. - Pregnancy and lactation: only prescribe if the potential benefit outweighs the risk. - Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Levofloxacin can interact with several medicines, altering its effectiveness or increasing toxicity risk.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce levofloxacin absorption. - Warfarin: may increase anticoagulant effect and bleeding risk. - NSAIDs (non‑steroidal anti‑inflammatory drugs): heightened risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely): - Theophylline: may raise serum theophylline concentrations. - Cyclosporine: increased risk of nephrotoxicity. - Diabetic agents: potential alteration of blood glucose control.