Oftacilox (Ciprofloxacin)

Ciprofloxacin, the active ingredient in Oftacilox, is a fluoroquinolone antibiotic presented as a strength/form for oral use. It treats a variety of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH USA supplies Oftacilox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ciprofloxacin is a broad‑spectrum antibacterial agent used in infections affecting several organ systems: - Urinary tract infection: helps eradicate common uropathogens and relieve symptoms. - Respiratory tract infection: targets bacteria that cause acute exacerbations of chronic bronchitis and community‑acquired pneumonia. - Skin and soft‑tissue infection: reduces bacterial load in cellulitis, wound infections and animal bites. - Gastrointestinal infection: effective against bacterial causes of traveller’s diarrhoea and dysentery. - Bone and joint infection: assists in treating osteomyelitis caused by susceptible organisms.

Ciprofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild stomach upset that often resolves without treatment. - Diarrhoea: loose stools that may be watery or contain mucus. - Headache: transient head pain of varying intensity. - Dizziness: sensation of light‑headedness or unsteadiness. - Rash: mild skin redness or itching.

Serious or Rare Side Effects: - Tendon rupture: sudden pain or swelling, especially in the Achilles tendon. - Peripheral neuropathy: tingling, numbness or burning sensations in extremities. - QT prolongation: irregular heart rhythm detectable on ECG. - Severe allergic reaction: swelling of face/lips, difficulty breathing, hives. - Clostridioides difficile infection: persistent diarrhoea with abdominal cramping.

Ciprofloxacin should be used with caution in specific clinical situations: - Renal impairment: dose adjustment may be required based on kidney function. - Hepatic impairment: monitor liver enzymes and adjust dose if necessary. - History of tendon disorders: avoid use in patients with prior tendon injury. - Concomitant QT‑prolonging drugs: monitor cardiac rhythm closely. - Pregnancy and lactation: only prescribe if benefits outweigh potential risks. Store at below 25°C: keep in the original container, protect from moisture and light.

Ciprofloxacin interacts with several medicines that can alter its efficacy or safety profile.

Major Interactions (Avoid): - Antacids containing aluminium or magnesium: reduce ciprofloxacin absorption. - Warfarin: may increase anticoagulant effect and bleeding risk. - Theophylline: can raise plasma theophylline levels, leading to toxicity.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of central nervous system stimulation. - Corticosteroids: combined use may heighten tendon‑rupture risk. - Diabetic agents (e.g., insulin, sulfonylureas): monitor blood glucose as ciprofloxacin can affect glycaemic control.