Ofost (Oxytocin)

Oxytocin, the active ingredient in Ofost, is a oxytocic agent presented as a injectable solution for intramuscular and intravenous use. It induces uterine contractions and facilitates milk ejection, primarily used in obstetric care.

GNH USA supplies Ofost as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Oxytocin is an oxytocic agent used in obstetric practice to modulate uterine activity.

Induction of labor: initiates regular uterine contractions to start labor. Augmentation of labor: strengthens insufficient contractions to progress labor. Control of postpartum hemorrhage: promotes uterine tone to reduce bleeding. Induction of uterine contraction after delivery: facilitates placental expulsion and reduces uterine atony.

Oxytocin may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Nausea - Uterine hyperstimulation - Headache - Abdominal pain

Serious or Rare Side Effects: - Cardiac arrhythmia - Water intoxication (hyponatremia) - Uterine rupture

When using Ofost, clinicians should observe specific safety measures.

Assess uterine tone before administration: ensure baseline contraction status. Monitor fetal heart rate: detect any distress promptly. Avoid use in fetal distress: excessive contractions may worsen condition. Use caution in cardiovascular disease: oxytocin can affect blood pressure. Adjust dose in patients with uterine scar: reduce risk of rupture. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Oxytocin can interact with several agents that affect uterine tone or cardiovascular function.

Major Interactions (Avoid): - Concomitant prostaglandins: may cause excessive uterine activity. - Ergot alkaloids: increase risk of severe hypertension. - Vasopressin antagonists: may reduce oxytocin efficacy.

Moderate Interactions (Monitor Closely): - Inhalational anesthetics (e.g., halothane): can potentiate uterine relaxation. - Magnesium sulfate: may diminish uterine response to oxytocin. - Beta‑adrenergic agonists: may counteract oxytocin‑induced contractions.