Ofloxacine Pch

Ofloxacin, the active ingredient in Ofloxacine Pch, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a variety of bacterial infections in adults and children as directed by a healthcare professional.

GNH USA supplies Ofloxacine Pch as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ofloxacin is a broad‑spectrum fluoroquinolone used to manage bacterial infections affecting several organ systems. - Urinary tract infection: eradicates susceptible uropathogens and resolves symptoms. - Acute bacterial sinusitis or exacerbations of chronic bronchitis: reduces bacterial load and improves respiratory function. - Skin and soft‑tissue infection: eliminates causative Gram‑negative and Gram‑positive organisms. - Uncomplicated gonorrhoea: provides rapid bacterial clearance. - Bacterial prostatitis: penetrates prostatic tissue to treat infection.

Ofloxacin, like other fluoroquinolones, may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Diarrhoea: may be watery and self‑limiting. - Headache: transient and often resolves without treatment. - Dizziness: occasional light‑headedness. - Abdominal pain: crampy discomfort. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Tendon rupture: especially Achilles tendon, may occur during or after therapy. - QT interval prolongation: can precipitate cardiac arrhythmias. - Severe allergic reactions: anaphylaxis or angioedema. - Clostridioides difficile‑associated diarrhoea: potentially life‑threatening. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Peripheral neuropathy: sensory disturbances that may be irreversible.

Before initiating Ofloxacin therapy, consider the following safety measures. - Assess renal function: adjust dose in patients with impaired clearance. - Avoid use in patients with known hypersensitivity to fluoroquinolones. - Monitor for tendon pain or swelling: discontinue if symptoms appear. - Use with caution in pregnancy or breastfeeding: only if benefits outweigh risks. - Avoid concomitant use with drugs that prolong the QT interval: monitor cardiac status. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Ofloxacin can interact with several medicines, requiring careful management.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: markedly reduce absorption. - Iron supplements: decrease oral bioavailability. - Warfarin: may increase INR and bleeding risk. - Cyclosporine: elevated cyclosporine concentrations. - Theophylline: increased plasma levels and toxicity.

Moderate Interactions (Monitor Closely): - NSAIDs: heightened risk of central nervous system effects. - Corticosteroids: additive risk of tendon rupture. - Oral hypoglycaemic agents: potential for enhanced hypoglycaemia. - Other QT‑prolonging agents: monitor ECG for arrhythmia. - CYP1A2 substrates (e.g., caffeine): possible increased exposure.