Ofloxacine Cristers

Ofloxacin, the active ingredient in Ofloxacine Cristers, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It targets a broad spectrum of Gram‑negative and Gram‑positive bacteria and is prescribed for various infections in adults and children under medical supervision.

GNH USA supplies Ofloxacine Cristers as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics across the European Union and other global markets, ensuring quality and regulatory compliance.

Ofloxacin is a fluoroquinolone antibacterial indicated for several bacterial infection categories. - Uncomplicated urinary tract infection: eradicates causative uropathogens and resolves symptoms. - Acute bacterial sinusitis: reduces bacterial load and improves sinus drainage. - Community‑acquired lower respiratory tract infection: treats susceptible Streptococcus pneumoniae and Haemophilus influenzae. - Skin and soft‑tissue infection: eliminates susceptible Staphylococcus aureus and Streptococci. - Gonorrhea (pharyngeal or genital): provides bactericidal activity against Neisseria gonorrhoeae.

Like all antibiotics, Ofloxacin may cause adverse reactions ranging from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Dizziness - Abdominal pain - Rash

Serious or Rare Side Effects: - Tendon rupture or tendinitis - Peripheral neuropathy - QT interval prolongation - Severe allergic reactions (anaphylaxis) - Clostridioides difficile‑associated diarrhea - Hepatic dysfunction

When prescribing Ofloxacin, clinicians should consider several safety measures to minimise risk. - Renal impairment: adjust dose or monitor renal function. - History of tendon disorders: avoid use or use with caution. - Cardiac arrhythmia risk: assess QT interval before therapy. - Concomitant CNS active drugs: monitor for seizures. - Pregnancy and lactation: use only if benefits outweigh risks. - Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Ofloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce Ofloxacin absorption. - Warfarin: may increase anticoagulant effect; monitor INR closely. - Cyclosporine: can raise serum cyclosporine levels, increasing toxicity risk.

Moderate Interactions (Monitor Closely): - NSAIDs (e.g., ibuprofen): may increase risk of central nervous system effects. - Theophylline: Ofloxacin may raise plasma theophylline concentrations. - Corticosteroids: combined use heightens risk of tendon rupture.