Ofloxacine Arrow

Ofloxacin, the active ingredient in Ofloxacine Arrow, is a fluoroquinolone presented as an oral dosage form for oral use. It treats a range of bacterial infections, including urinary, respiratory, skin and gastrointestinal infections, in adult patients as prescribed by a healthcare professional and is commonly used in community and hospital settings.

GNH USA supplies Ofloxacine Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ofloxacin is used to treat bacterial infections affecting several organ systems.

- Urinary tract infections: effective in treating uncomplicated infections caused by susceptible bacteria. - Respiratory tract infections: helps clear infections such as acute exacerbations of chronic bronchitis and community‑acquired pneumonia. - Skin and soft tissue infections: used for cellulitis, wound infections and other dermal bacterial conditions. - Gastrointestinal infections: indicated for bacterial diarrhoea and enteric infections caused by susceptible organisms.

Ofloxacin may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhoea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: light‑headed sensation. - Abdominal pain: cramping or discomfort. - Rash: mild skin redness or itching.

Serious or Rare Side Effects: - Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon. - Peripheral neuropathy: numbness, tingling or burning sensations in extremities. - QT interval prolongation: risk of cardiac arrhythmias. - Severe allergic reactions: anaphylaxis, swelling of face or throat. - Clostridioides difficile infection: severe colitis with watery diarrhoea. - Hepatic dysfunction: elevated liver enzymes or jaundice.

When prescribing Ofloxacin, clinicians should consider several precautionary measures to minimize risks.

- Renal impairment: assess kidney function and adjust dose if necessary. - History of tendon disorders: avoid use in patients with prior tendon injury. - Concomitant QT‑prolonging drugs: monitor cardiac rhythm closely. - Pregnancy and lactation: use only when benefits outweigh potential risks. - Age > 60 years: increased susceptibility to tendon injury and CNS effects. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Ofloxacin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce ofloxacin absorption. - Warfarin: may increase anticoagulant effect and bleeding risk. - Theophylline: can raise plasma theophylline concentrations. - Co‑administration with other fluoroquinolones: additive toxicity. - Systemic glucocorticoids: heightened risk of tendon rupture.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase risk of central nervous system stimulation. - Diabetes medications: potential alteration of glucose control. - Cyclosporine: may elevate cyclosporine serum levels. - Rifampin: can lower ofloxacin concentrations, reducing efficacy. - Oral contraceptives: possible reduction in contraceptive effectiveness.