Ofloxacine 400 Pch

Ofloxacin, the active ingredient in Ofloxacine 400 Pch, is a fluoroquinolone antibiotic presented as a 400 mg tablet for oral administration. It is used to treat a range of bacterial infections in adults and, when appropriate, in pediatric patients under medical supervision.

GNH USA supplies Ofloxacine 400 Pch as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to quality‑assured medicines.

Ofloxacin is a fluoroquinolone antibiotic that interferes with bacterial DNA replication, making it effective for several common bacterial infections.

- Urinary tract infection: eradicates susceptible uropathogens and resolves urinary symptoms. - Respiratory tract infection: treats acute exacerbations of chronic bronchitis and community‑acquired pneumonia caused by susceptible bacteria. - Skin and soft‑tissue infection: clears infections such as cellulitis and impetigo. - Sexually transmitted infection (gonorrhoea): eliminates Neisseria gonorrhoeae strains sensitive to ofloxacin. - Traveler's diarrhea: combats bacterial causes of acute diarrhoea acquired abroad.

Common side effects are generally mild and self‑limiting.

Common Side Effects: - Nausea: transient stomach upset. - Diarrhoea: loose stools occurring during therapy. - Headache: mild to moderate intensity. - Dizziness: occasional light‑headed feeling. - Abdominal pain: cramping or discomfort. - Rash: mild skin irritation.

Serious or Rare Side Effects: - Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon. - QT interval prolongation: risk of cardiac arrhythmias. - Severe allergic reactions: anaphylaxis, angioedema, or bronchospasm. - Clostridioides difficile colitis: severe diarrhoea due to gut flora disruption. - Peripheral neuropathy: tingling or numbness in extremities. - Stevens‑Johnson syndrome: severe skin and mucous membrane reactions.

Before prescribing Ofloxacine, clinicians should consider several safety factors.

- Assess renal function: adjust dose in patients with impaired clearance. - Avoid in patients with known hypersensitivity to fluoroquinolones. - Monitor for tendon pain: discontinue immediately if tendinitis or rupture occurs. - Use with caution in pregnancy or breastfeeding: safety data are limited. - Avoid concurrent use with other QT‑prolonging agents: evaluate cardiac risk. - Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Ofloxacin may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Tizanidine: co‑administration can cause marked hypotension and sedation. - Drugs that prolong QT interval (e.g., macrolides, other fluoroquinolones): increased risk of arrhythmia. - Antacids containing magnesium or aluminum, and sucralfate: reduce ofloxacin absorption.

Moderate Interactions (Monitor Closely): - Corticosteroids: heightened risk of tendon rupture; monitor musculoskeletal symptoms. - NSAIDs: may amplify central nervous system effects such as dizziness. - Warfarin: potential enhancement of anticoagulant effect; check INR regularly.