GNH USA

Europe — EMA

Ofloxacin-Ophtal® Sine

GNH USA supplies Ofloxacin-Ophtal® Sine (Ofloxacin), a fluoroquinolone antibiotic for bacterial conjunctivitis, corneal ulcers and post‑operative eye

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What is Ofloxacin?

Ofloxacin, the active ingredient in Ofloxacin-Ophtal® Sine, is a fluoroquinolone antibiotic presented as an ocular solution for topical eye use. It treats bacterial eye infections such as conjunctivitis, corneal ulcers and post‑operative infections in both adults and children.

GNH USA supplies Ofloxacin-Ophtal® Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ofloxacin used for?

Ofloxacin ophthalmic solution is a fluoroquinolone antibiotic used to treat bacterial infections of the eye.

- Bacterial conjunctivitis: reduces bacterial load and resolves inflammation. - Bacterial keratitis (corneal ulcer): promotes healing and prevents disease progression. - Post‑operative ocular infection: prevents bacterial contamination after eye surgery.

What are the side effects of Ofloxacin?

Common Side Effects: - Transient stinging or burning - Redness of the eye - Tearing - Mild conjunctival hyperemia

Serious or Rare Side Effects: - Corneal ulceration - Severe allergic reaction (anaphylaxis) - Stevens‑Johnson syndrome

What precautions apply to Ofloxacin?

Before using Ofloxacin‑Ophtal® Sine, consider the following precautions: - Allergy assessment: avoid if the patient has known hypersensitivity to fluoroquinolones or any component of the solution. - Contact lens use: discontinue lenses during treatment to reduce irritation risk. - Systemic absorption: minimal, but avoid in patients with tendon disorders. - Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation. - Resistance: limit use to confirmed bacterial infections to prevent antimicrobial resistance. - Store at room temperature: keep in the original container, protect from light and moisture.

What does Ofloxacin interact with?

Ofloxacin‑Ophtal® Sine may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid): - Systemic fluoroquinolones: concurrent use may increase risk of tendon rupture. - Corticosteroid eye drops: may mask infection signs, use with caution. - Anticholinergic agents: may reduce ocular secretions, monitor closely.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation. - Herbal eye preparations: potential additive irritation.

Frequently asked questions

What is Ofloxacin-Ophtal® Sine used for?+
Ofloxacin-Ophtal® Sine is an ophthalmic solution indicated for the treatment of bacterial eye infections such as conjunctivitis, corneal ulcers (bacterial keratitis) and infections that may occur after ocular surgery. It is applied directly to the eye to eradicate susceptible bacteria and promote healing.
How does Ofloxacin work?+
Ofloxacin belongs to the fluoroquinolone class and works by inhibiting bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication and transcription. By blocking them, Ofloxacin prevents bacterial cell division, leading to bacterial death and clearance of the infection.
What is the usual dose of Ofloxacin‑Ophtal® Sine?+
The specific dosing regimen for Ofloxacin‑Ophtal® Sine is determined by the prescribing clinician based on the type and severity of the infection, patient age and response to therapy. The prescriber will indicate the number of drops and frequency appropriate for each case.
Is Ofloxacin‑Ophtal® Sine safe during pregnancy or breastfeeding?+
Safety data for topical Ofloxacin in pregnancy and lactation are limited. It should be used only when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician after a thorough risk‑benefit assessment.
How do I order Ofloxacin‑Ophtal® Sine from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.
How does Ofloxacin‑Ophtal® Sine compare with other eye antibiotics?+
Ofloxacin offers broad‑spectrum activity against Gram‑negative and many Gram‑positive ocular pathogens, similar to other fluoroquinolones such as ciprofloxacin. Compared with older agents like chloramphenicol, Ofloxacin generally provides higher potency and a lower risk of resistance, but the choice depends on local susceptibility patterns and physician preference.
How should Ofloxacin‑Ophtal® Sine be stored and handled?+
Store the ocular solution at room temperature, below 25 °C, in its original container. Protect it from direct sunlight and moisture. Keep the bottle tightly closed when not in use and discard any solution that appears discolored or contaminated.
How is Ofloxacin‑Ophtal® Sine administered?+
The solution is applied topically to the affected eye(s). The prescriber will advise the number of drops per dose and the frequency (e.g., one drop every 2‑4 hours). Patients should wash their hands before and after instillation and avoid touching the tip of the bottle to the eye or any surface.
What are the most serious risks associated with Ofloxacin‑Ophtal® Sine?+
Serious adverse events, although rare, include corneal ulceration, severe allergic reactions such as anaphylaxis, and systemic hypersensitivity syndromes like Stevens‑Johnson syndrome. Any sudden loss of vision, intense eye pain, or signs of a severe allergic reaction require immediate medical attention.
Who should not use Ofloxacin‑Ophtal® Sine?+
Patients with a known hypersensitivity to Ofloxacin, other fluoroquinolones, or any excipients in the formulation should avoid this product. It is also contraindicated in individuals with a history of tendon disorders related to fluoroquinolone use, and it should be used with caution in patients with pre‑existing corneal disease.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Ofloxacin
Route
Ocular Use
Manufacturer
Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh
Origin
EU

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