Oflovir (Ofloxacin)

Ofloxacin, the active ingredient in Oflovir, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It is employed to treat a variety of bacterial infections in adults and children when prescribed by a qualified healthcare professional. The drug works by targeting bacterial DNA processes, providing broad‑spectrum activity against Gram‑negative and Gram‑positive organisms.

GNH USA supplies Oflovir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ofloxacin is a fluoroquinolone antibiotic indicated for several bacterial infections across different organ systems.

- Urinary Tract Infection: eradicates susceptible uropathogens, relieving symptoms and preventing recurrence. - Respiratory Tract Infection: treats acute exacerbations of chronic bronchitis and community‑acquired pneumonia caused by susceptible bacteria. - Skin and Soft Tissue Infection: clears infections such as cellulitis and wound infections due to Gram‑negative organisms. - Gonorrhea: provides single‑dose therapy for uncomplicated Neisseria gonorrhoeae infections. - Intra‑abdominal Infection: used as part of combination therapy for complicated intra‑abdominal infections after surgical intervention.

Ofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Rash

Serious or Rare Side Effects: - Tendon rupture or tendinitis - QT interval prolongation - Severe allergic reaction (anaphylaxis) - Clostridioides difficile‑associated colitis

When prescribing Ofloxacin, clinicians should observe several precautionary measures to minimize risk. - Assess renal function: adjust dose in patients with impaired clearance. - Avoid in patients with known tendon disorders: risk of tendon injury is increased. - Use cautiously in elderly: higher susceptibility to tendon rupture and CNS effects. - Monitor cardiac status: avoid in individuals with prolonged QT interval or taking other QT‑prolonging agents. - Store at room temperature: keep in original container, protect from moisture and light.

Ofloxacin interacts with several medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid): - Tizanidine: concurrent use can cause profound hypotension and should be avoided. - Antacids containing magnesium or aluminum: they reduce Ofloxacin absorption; separate dosing by at least 2 hours. - Co‑administration with other fluoroquinolones: increases risk of tendon toxicity and should be avoided.

Moderate Interactions (Monitor Closely): - Theophylline (CYP1A2 substrate): Ofloxacin may raise plasma levels, requiring monitoring for toxicity. - Warfarin: potentiates anticoagulant effect, necessitating frequent INR checks.