GNH USA

Europe — EMA

Odyralduo (Dorzolamide, Timolol)

GNH USA supplies Odyralduo (Dorzolamide/Timolol), a carbonic anhydrase inhibitor and beta‑blocker for glaucoma and ocular hypertension.

Dorzolamide, Timolol

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What is Dorzolamide, Timolol?

Dorzolamide, the active ingredient in Odyralduo, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular use. It reduces intra‑ocular pressure in patients with open‑angle glaucoma or ocular hypertension.

GNH USA supplies Odyralduo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, eye‑care centres and clinics worldwide.

What is Dorzolamide, Timolol used for?

Odyralduo, a combination of dorzolamide and timolol, is used to lower intra‑ocular pressure in ocular conditions.

Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression. Ocular hypertension: lowers pressure to prevent conversion to glaucoma. Secondary glaucoma (e.g., pseudoexfoliative): helps control pressure when monotherapy is insufficient.

What are the side effects of Dorzolamide, Timolol?

Common Side Effects: - Eye irritation or burning sensation. - Bitter taste after instillation. - Transient blurred vision. - Headache.

Serious or Rare Side Effects: - Severe allergic reaction (e.g., angio‑edema, anaphylaxis). - Marked bradycardia or heart block. - Bronchospasm in susceptible individuals. - Systemic hypotension or syncope. - Rare dermatologic reactions such as Stevens‑Johnson syndrome.

What precautions apply to Dorzolamide, Timolol?

Before initiating therapy, consider the following precautions: - Assess renal function: dorzolamide is renally excreted. - Monitor cardiac status: timolol may cause bradycardia. - Avoid in patients with severe COPD or asthma. - Caution in individuals with sulfonamide allergy. - Store at room temperature: keep in the original container, protect from light and moisture.

What does Dorzolamide, Timolol interact with?

Odyralduo may interact with other medicines as follows.

Major Interactions (Avoid): - Non‑selective beta‑blockers: additive bradycardia. - Systemic carbonic anhydrase inhibitors: increased risk of metabolic acidosis. - Monoamine oxidase inhibitors: may enhance hypotensive effect. - Other ocular beta‑blockers: excessive ocular hypotension.

Moderate Interactions (Monitor Closely): - Diuretics: may affect potassium balance. - Anticholinergic agents: may reduce ocular drug absorption. - Corticosteroid eye drops: may increase intra‑ocular pressure.

Frequently asked questions

What is Odyralduo used for?+
Odyralduo is a fixed‑dose ophthalmic solution that combines dorzolamide and timolol to lower intra‑ocular pressure. It is prescribed for conditions such as open‑angle glaucoma, ocular hypertension, and certain secondary glaucomas where pressure reduction is needed to protect the optic nerve.
How does dorzolamide work in Odyralduo?+
Dorzolamide inhibits the enzyme carbonic anhydrase in the ciliary body of the eye. This inhibition reduces the production of aqueous humor, the fluid that maintains intra‑ocular pressure. When paired with timolol, which blocks beta‑adrenergic receptors, the overall effect is a significant decrease in eye pressure.
What is the usual dose of Odyralduo?+
The dosing regimen for Odyralduo is determined by the prescribing ophthalmologist based on the patient’s condition, response, and tolerance. Typically, one drop is instilled in the affected eye(s) once or twice daily, but the exact schedule should follow the prescriber’s instructions.
Is Odyralduo safe during pregnancy or breastfeeding?+
Safety data for dorzolamide and timolol during pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Odyralduo from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.
How does Odyralduo compare with other glaucoma eye drops?+
Odyralduo combines two mechanisms—carbonic anhydrase inhibition and beta‑blockade—into a single formulation, offering greater pressure‑lowering efficacy than many single‑agent drops. Compared with prostaglandin analogues, it may have a different side‑effect profile, such as less eyelash growth but more ocular irritation. Choice of therapy depends on individual patient factors and physician judgment.
What are the storage and handling requirements for Odyralduo?+
Odyralduo should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light, and avoid exposure to moisture. Do not freeze the solution. If the product appears discolored or contains particles, discard it.
How is Odyralduo administered?+
Odyralduo is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a small pocket, and instill the prescribed number of drops without touching the tip of the bottle to the eye or any surface. Close the eye gently after administration.
What are the most serious risks associated with Odyralduo?+
Serious risks include severe allergic reactions (e.g., angio‑edema, anaphylaxis), marked bradycardia or heart block, bronchospasm in patients with reactive airway disease, and systemic hypotension. Patients should be instructed to seek immediate medical attention if they experience symptoms such as difficulty breathing, rapid weight gain, swelling, or fainting.
Who should not use Odyralduo?+
Odyralduo is contraindicated in patients with known hypersensitivity to dorzolamide, timolol, sulfonamides, or any component of the formulation. It should also be avoided in individuals with severe sinus bradycardia, second‑ or third‑degree heart block, uncontrolled asthma, or chronic obstructive pulmonary disease without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Dorzolamide, Timolol
Route
Ocular Use
Manufacturer
Orifarm Healthcare A/S
Origin
EU

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