Europe — EMA
Odrik (Trandolapril)
GNH USA supplies Odrik (Trandolapril), an ACE inhibitor for hypertension, heart failure and post‑myocardial infarction. Request a quote for global supply.
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What is Trandolapril?
Trandolapril, the active ingredient in Odrik, is an ACE (Angiotensin-Converting Enzyme) Inhibitor presented as a tablet for oral use. It is employed in the management of hypertension and certain cardiac conditions in adult patients. GNH USA supplies Odrik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
GNH USA supplies Odrik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Trandolapril used for?
Trandolapril is an ACE inhibitor that acts on the renin‑angiotensin‑aldosterone system to lower blood pressure and protect the heart. - Hypertension: helps achieve target blood pressure levels and reduces cardiovascular risk. - Chronic heart failure: improves symptoms and decreases hospitalisation rates. - Post‑myocardial infarction: aids ventricular remodeling prevention and supports long‑term survival.
What are the side effects of Trandolapril?
Adverse reactions to trandolapril may vary in frequency and severity.
Common Side Effects: - Cough: dry, persistent throat irritation. - Dizziness: especially upon standing quickly. - Headache: mild to moderate intensity. - Fatigue: general feeling of tiredness. - Hyperkalemia: elevated blood potassium levels. - Renal function changes: modest rise in serum creatinine.
Serious or Rare Side Effects: - Angioedema: swelling of face, lips, tongue or airway. - Severe hypotension: marked drop in blood pressure causing faintness. - Acute renal failure: rapid decline in kidney function. - Hepatic injury: elevated liver enzymes or hepatitis. - Neutropenia: low white‑blood‑cell count. - Anaphylaxis: life‑threatening allergic reaction.
What precautions apply to Trandolapril?
When prescribing trandolapril, clinicians should consider several safety aspects. - Renal impairment: monitor serum creatinine and adjust dose if needed. - Hyperkalemia risk: check potassium levels regularly. - Pregnancy: contraindicated in the second and third trimesters. - Concomitant diuretics: may enhance blood‑pressure lowering effect. - Elderly patients: start with lower dose and titrate cautiously. - Store at below 25°C: keep in the original container, protect from moisture and light.
What does Trandolapril interact with?
Trandolapril may interact with other medicines, requiring vigilance.
Major Interactions (Avoid): - Aliskiren: combined use can cause excessive hypotension and renal dysfunction. - Potassium‑sparing diuretics: increase risk of hyper‑kalemia. - NSAIDs: may blunt antihypertensive effect and worsen renal function.
Moderate Interactions (Monitor Closely): - Lithium: ACE inhibition can raise lithium levels, risking toxicity. - Other antihypertensives: additive blood‑pressure lowering may require dose adjustment. - Antacids/chelating agents: may reduce absorption of trandolapril.
