Europe — EMA
Octaplasma (Human Plasma Protein)
Human plasma protein, the active ingredient in Octaplasma, is a plasma‑derived product presented as a sterile liquid for intravenous use.
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What is Human Plasma Protein?
Human plasma protein, the active ingredient in Octaplasma, is a plasma‑derived product presented as a sterile liquid for intravenous use. It is used to support hemostasis in patients with bleeding disorders or massive transfusion needs. GNH USA supplies Octaplasma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide.
GNH USA supplies Octaplasma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide.
What is Human Plasma Protein used for?
Octaplasma is employed in clinical situations that require replacement of multiple coagulation factors and plasma volume. - Massive transfusion protocols: helps to restore clotting capacity and volume in patients receiving large volumes of blood components. - Liver transplantation: provides balanced plasma proteins to aid coagulation during the procedure. - Congenital coagulation factor deficiencies: supplies missing plasma‑derived factors to improve clotting. - Cardiac surgery : supports hemostasis during and after cardiac procedures. - Trauma‑related bleeding : contributes to rapid hemostatic control in severe injury.
What are the side effects of Human Plasma Protein?
Octaplasma may elicit a range of infusion‑related reactions.
Common Side Effects: - Mild fever - Chills - Headache - Nausea - Transient hypotension - Redness at the infusion site
Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Acute hemolytic transfusion reaction - Transfusion‑related acute lung injury (TRALI) - Volume overload leading to pulmonary edema - Disseminated intravascular coagulation (D血 D ).
What precautions apply to Human Plasma Protein?
Octaplasma should be administered with careful clinical monitoring. - Verify patient identity and blood type: ensure compatibility before infusion. - Assess for history of allergic reactions: watch for signs of hypersensitivity. - Monitor vital signs during infusion: watch for hypotension or fever. - Adjust infusion rate: slower rates may reduce reaction risk. - Use in patients with fluid overload risk: consider diuretics or alternative products. - Store at 2-8°C: keep refrigerated ; protect from light and do not freeze.
What does Human Plasma Protein interact with?
Octaplasma may interact with other blood products and medications that affect coagulation.
Major Interactions (Avoid): - Concomitant use of high‑dose anticoagulants (e.g., unfractionated heparin) may increase bleeding risk. - Concurrent treatment with pro‑ g g \
