GNH USA

Europe — EMA

O-Biotic (Dexamethasone, Tobramycin)

GNH USA supplies O-Biotic (Dexamethasone, Tobramycin), a corticosteroid‑antibiotic combination for ocular inflammation and bacterial eye infections.

Dexamethasone, Tobramycin

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What is Dexamethasone, Tobramycin?

Dexamethasone and Tobramycin, the active ingredients in O-Biotic, are a corticosteroid and an aminoglycoside antibiotic presented as a topical ophthalmic suspension for ocular use. They treat inflammation and bacterial infection in the eye, providing combined anti‑inflammatory and antimicrobial activity. GNH USA supplies O-Biotic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Dexamethasone, Tobramycin used for?

O-Biotic, a combination of dexamethasone and tobramycin, is used in ophthalmology to address inflammatory and bacterial conditions.

- Bacterial conjunctivitis: reduces bacterial load and alleviates associated redness. - Post‑operative ocular inflammation: controls swelling and pain after eye surgery. - Bacterial keratitis: combats infection while suppressing inflammatory response.

What are the side effects of Dexamethasone, Tobramycin?

Adverse reactions may occur with ocular use of O-Biotic.

Common Side Effects: - Eye irritation or burning sensation. - Transient blurred vision. - Increased intra‑ocular pressure. - Ocular discomfort or foreign‑body sensation.

Serious or Rare Side Effects: - Allergic reaction such as eyelid swelling or rash. - Secondary ocular infection or fungal overgrowth. - Corneal ulceration or thinning. - Glaucoma development. - Cataract formation with prolonged use.

What precautions apply to Dexamethasone, Tobramycin?

Use O-Biotic only under professional supervision and observe the following precautions.

- Pregnancy: consult a healthcare provider; risk category is C. - Breastfeeding: caution advised as the drug may be excreted in milk. - Contact lens wearers: avoid use; may cause irritation. - Patients with viral eye infections: do not use; may worsen condition. - Store below 25°C: keep in the original pack, protect from moisture.

What does Dexamethasone, Tobramycin interact with?

Consider potential drug interactions when prescribing O-Biotic.

Major Interactions (Avoid): - Systemic corticosteroids: may increase systemic glucocorticoid effects. - Other ophthalmic NSAIDs: additive ocular irritation. - Anticholinergic eye drops: may reduce dexamethasone efficacy.

Moderate Interactions (Monitor Closely): - Concurrent topical antibiotics (non‑tobramycin): possible antagonism. - Glaucoma medications: monitor intra‑ocular pressure closely. - Preservative‑containing contact lens solutions: may heighten irritation.

Frequently asked questions

What is O-Biotic used for?+
O-Biotic is a combination ophthalmic suspension containing dexamethasone and tobramycin. It is used to treat ocular inflammation and bacterial eye infections such as conjunctivitis, post‑operative inflammation, and bacterial keratitis, providing both anti‑inflammatory and antimicrobial effects.
How does dexamethasone work in O-Biotic?+
Dexamethasone is a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors. This interaction modulates gene expression, suppressing the release of inflammatory mediators, reducing edema, and inhibiting leukocyte migration, thereby decreasing ocular inflammation.
What is the usual dose of O-Biotic?+
The dosage of O-Biotic is determined by the prescribing clinician based on the specific condition, severity, and patient factors. The prescriber will specify the number of drops, frequency, and duration appropriate for each case.
Is O-Biotic safe during pregnancy or breastfeeding?+
Pregnancy and breastfeeding considerations should be discussed with a healthcare professional. Dexamethasone is classified as pregnancy category C, and both ingredients may be excreted in breast milk, so caution is advised and benefits must outweigh potential risks.
How do I order O-Biotic from GNH USA?+
To order O-Biotic, submit an enquiry on the product page at gnh-usa.com, indicating the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does O-Biotic compare with other eye antibiotics?+
O-Biotic combines a corticosteroid (dexamethasone) with an aminoglycoside antibiotic (tobramycin), offering both anti‑inflammatory and antibacterial activity in a single formulation. In contrast, many eye antibiotics lack anti‑inflammatory properties, requiring separate steroid therapy for inflammation.
What are the storage and handling requirements for O-Biotic?+
O-Biotic should be stored below 25 °C, in its original container, protected from moisture and direct sunlight. Keep the suspension tightly sealed and avoid freezing. Follow any additional handling instructions provided on the label.
How is O-Biotic administered?+
O-Biotic is applied as an ophthalmic suspension. The prescribed number of drops is instilled into the affected eye(s) at the frequency indicated by the prescriber, typically using a sterile dropper to avoid contamination.
What are the most serious risks associated with O-Biotic?+
Serious risks include allergic reactions such as eyelid swelling or rash, secondary ocular infections, corneal ulceration, increased intra‑ocular pressure leading to glaucoma, and cataract formation with prolonged use. Patients should be monitored for these events.
Who should not use O-Biotic?+
O-Biotic should be avoided in patients with known hypersensitivity to dexamethasone, tobramycin, or any formulation components. It is also contraindicated in viral eye infections (e.g., herpes simplex keratitis) and in individuals for whom corticosteroid use is prohibited.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Dexamethasone, Tobramycin
Route
Ocular Use
Manufacturer
Zwitter Pharmaceuticals Επε
Origin
EU

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