Nystatin Acis

Nystatin, the active ingredient in Nystatin Acis, is an antifungal polyol presented as a topical suspension for oral and gastrointestinal use. It treats Candida infections of the mouth, skin and gastrointestinal tract in patients of all ages.

GNH USA supplies Nystatin Acis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Nystatin is an antifungal agent that acts on Candida species affecting mucosal surfaces and skin. - Oropharyngeal candidiasis: reduces fungal load and relieves symptoms of oral thrush. - Esophageal candidiasis: helps clear infection and improve swallowing. - Cutaneous candidiasis: treats skin infections such as diaper rash and intertrigo. - Gastrointestinal candidiasis: controls fungal overgrowth in the GI tract. - Prophylaxis in immunocompromised patients: prevents Candida colonisation during chemotherapy or transplant.

Nystatin is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild gastrointestinal discomfort. - Vomiting: occasional episodes after oral administration. - Diarrhea: loose stools during treatment. - Abdominal pain: cramping or discomfort. - Taste alteration: temporary change in taste perception. - Local irritation: burning or itching at the site of topical application.

Serious or Rare Side Effects: - Severe allergic reaction: rash, itching, swelling, or anaphylaxis. - Hepatic dysfunction: rare liver enzyme elevations. - Stevens‑Johnson syndrome: severe skin reaction. - Toxic epidermal necrolysis: extensive skin detachment. - Hemolysis: rare in patients with G6PD deficiency. - Systemic fungal infection: extremely rare due to poor absorption.

Before using Nystatin, consider the following safety measures. - Confirm diagnosis: ensure infection is caused by Candida species. - Hypersensitivity: avoid if known allergy to nystatin or formulation excipients. - Systemic infection: not indicated for invasive candidiasis; use systemic antifungals instead. - Infants and neonates: monitor closely for tolerance and dosing accuracy. - Concomitant antibiotics: watch for overgrowth of resistant organisms. - Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Nystatin may interact with other medications, though systemic absorption is minimal.

Major Interactions (Avoid): - Systemic azole antifungals (e.g., fluconazole): may increase risk of toxicity when combined. - Broad‑spectrum antibiotics: can alter gut flora and affect nystatin efficacy.

Moderate Interactions (Monitor Closely): - Antacids containing aluminum or magnesium: may reduce oral absorption. - Oral corticosteroids: may increase risk of oral candidiasis recurrence. - Immunosuppressants: monitor for opportunistic infections. - Probiotics: assess for potential synergistic effects on gut flora. - Vitamin supplements (high dose): observe for gastrointestinal upset.