Nystan (Nystatin)

Nystatin, the active ingredient in Nystan, is a polyol polyene antifungal presented as an oral formulation for oral use. It treats Candida infections of the mouth, throat, gastrointestinal tract and skin in patients of all ages. GNH USA supplies Nystan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nystatin is used to manage fungal infections caused by Candida species affecting the mucosal and gastrointestinal pathways. - Oral thrush (candidiasis): reduces fungal load and relieves symptoms in the oral cavity. - Esophageal candidiasis: provides local antifungal effect to clear infection. - Gastrointestinal candidiasis: treats overgrowth and associated discomfort. - Cutaneous candidiasis (e.g., diaper rash): controls fungal growth on skin.

Nystatin may cause adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild stomach upset after oral administration. - Vomiting: occasional expulsion of stomach contents. - Diarrhea: loose stools during treatment. - Abdominal cramps: transient discomfort. - Taste alteration: temporary change in flavor perception. - Mild skin irritation: localized rash at mucosal sites.

Serious or Rare Side Effects: - Allergic reaction: rash, urticaria, or anaphylaxis. - Hepatotoxicity: signs of liver dysfunction. - Severe colitis: persistent abdominal pain and bloody stools. - Renal impairment: decreased kidney function. - Hemolysis: breakdown of red blood cells. - Hypersensitivity pneumonitis: respiratory distress.

Before using Nystan, consider the following safety measures. - Renal impairment: monitor kidney function during therapy. - Hepatic disease: use with caution in patients with liver disorders. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: evaluate risk versus benefit with a physician. - Concomitant medications: review all drugs for potential interactions. - Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nystan may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid): - Nephrotoxic agents (e.g., aminoglycosides): increased risk of renal toxicity. - Systemic antifungals (e.g., amphotericin B): additive toxicity and overlapping side effects.

Moderate Interactions (Monitor Closely): - Antacids containing aluminum or magnesium: may reduce Nystatin absorption. - Oral contraceptives: possible reduction in efficacy. - Proton pump inhibitors: altered gastric pH may affect drug activity.