Nurofenteen, Limone (Ibuprofen)

Ibuprofen, the active ingredient in Nurofenteen, Limone, is a non‑steroidal anti‑inflammatory drug presented as a 200 mg tablet for oral use. It relieves pain, reduces fever and diminishes inflammation in adults and children when appropriate.

GNH USA supplies Nurofenteen, Limone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to provide analgesic and antipyretic effects across several common conditions. - Headache: reduces pain intensity and improves functional ability. - Dental pain: alleviates post‑extraction and procedural discomfort. - Musculoskeletal pain: eases aches associated with strains, sprains and arthritis. - Fever: lowers elevated body temperature in febrile patients. - Menstrual cramps: diminishes dysmenorrhoeic pain.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Dyspepsia: mild stomach upset or discomfort. - Nausea: feeling of queasiness. - Headache: transient head pain. - Dizziness: light‑headed sensation. - Rash: mild skin redness or itching. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal bleeding: black or tarry stools, vomiting blood. - Peptic ulcer perforation: sudden severe abdominal pain. - Renal impairment: reduced urine output or swelling. - Anaphylaxis: rapid onset of hives, swelling, airway compromise. - Hepatotoxicity: jaundice or abnormal liver enzymes. - Stevens‑Johnson syndrome: severe skin blistering and detachment.

Before initiating ibuprofen therapy, consider the following safety measures: - Assess gastrointestinal risk: patients with a history of ulcers or bleeding need protection. - Evaluate renal function: monitor creatinine in those with chronic kidney disease. - Check cardiovascular status: use cautiously in patients with hypertension or heart disease. - Review concomitant medications: avoid NSAID combinations that increase bleeding risk. - Pregnancy and lactation: limit use to the shortest duration and lowest effective dose. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: risk of reduced kidney perfusion. - Lithium: increased serum lithium levels. - Methotrexate: decreased renal clearance leading to toxicity.