Nurofenplast (Ibuprofen)

Ibuprofen, the active ingredient in Nurofenplast, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a strength‑free oral formulation for systemic use. It is commonly used to relieve mild to moderate pain, reduce fever, and decrease inflammation in adults and children.

GNH USA supplies Nurofenplast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to provide analgesic and antipyretic effects. - Headache: alleviates pain associated with tension‑type and mild migraine headaches. - Musculoskeletal pain: reduces discomfort from sprains, strains and minor joint inflammation. - Fever: lowers elevated body temperature in febrile conditions. - Dental pain: eases postoperative or acute toothache discomfort.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache not related to the underlying condition. - Dizziness: occasional light‑headed feeling. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: may present with black stools or vomiting blood. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Renal impairment: sudden decrease in urine output or swelling. - Hepatotoxicity: abnormal liver enzymes or jaundice. - Anaphylaxis: acute, life‑threatening allergic reaction with airway compromise.

Before initiating ibuprofen therapy, consider the following safety measures: - Assess renal function: patients with chronic kidney disease should be evaluated. - Evaluate cardiovascular risk: use cautiously in individuals with hypertension or heart disease. - Review gastrointestinal history: avoid in those with active ulcers or recent GI bleeding. - Monitor for asthma exacerbation: ibuprofen can trigger bronchospasm in aspirin‑sensitive patients. - Pregnancy and lactation: limit use to the lowest effective dose and shortest duration, and only if clearly needed. - Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Ibuprofen may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin aspirin: additive gastrointestinal toxicity. - Selective COX‑2 inhibitors (e.g., celecoxib): heightened cardiovascular risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors (e.g., enalapril): possible reduction in antihypertensive effect. - Diuretics (e.g., furosemide): may diminish renal clearance of ibuprofen. - Lithium: increased lithium serum levels. - Methotrexate: reduced renal elimination leading to toxicity.