Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate)

Ibuprofen, the active ingredient in Nurofen Plus, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a combination tablet for oral use. It reduces pain, inflammation and fever, and is commonly used in adults who need stronger relief than ibuprofen alone. Codeine phosphate hemihydrate, the second active ingredient, is an opioid analgesic that enhances pain control.

GNH USA supplies Nurofen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nurofen Plus combines ibuprofen and codeine to address pain conditions that involve inflammatory pathways.

- Dental pain: provides relief of moderate to severe dental discomfort after procedures. - Musculoskeletal pain: eases pain and inflammation associated with strains, sprains and low‑back pain. - Post‑operative pain: helps manage pain following minor surgical interventions. - Migraine headache: reduces headache intensity when standard analgesics are insufficient. - Dysmenorrhoea: alleviates painful menstrual cramps that are not controlled by ibuprofen alone.

Side effects may occur with any medication and vary in frequency.

Common Side Effects: - Nausea and vomiting. - Constipation. - Dizziness. - Drowsiness. - Upper gastrointestinal discomfort. - Mild skin rash.

Serious or Rare Side Effects: - Severe gastrointestinal bleeding or ulceration. - Respiratory depression. - Allergic anaphylaxis. - Hepatotoxicity. - Seizures. - Severe skin reactions such as Stevens‑Johnson syndrome.

When using Nurofen Plus, consider the following safety measures:

- Assess renal function: patients with impaired kidney function may require dose adjustment or avoidance. - Monitor for gastrointestinal risk: individuals with a history of ulcers or bleeding should use caution. - Evaluate hepatic function: liver disease may increase risk of toxicity. - Avoid concurrent CNS depressants: combining with alcohol or sedatives can enhance drowsiness. - Pregnancy and lactation: use only if clearly needed and prescribed. - Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Nurofen Plus can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.\n- Selective serotonin reuptake inhibitors (SSRIs) and SNRIs: increased gastrointestinal bleeding risk.

Moderate Interactions (Monitor Closely): - Diuretics (e.g., furosemide): may reduce renal clearance of ibuprofen. - Antihypertensive agents: ibuprofen may blunt the blood‑pressure‑lowering effect. - CYP2D6 inhibitors: can affect conversion of codeine to morphine, altering analgesic effect.