Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate)

Ibuprofen, the active ingredient in Nurofen Plus, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a combined tablet for oral use. It is formulated with codeine phosphate hemihydrate to provide analgesic and anti‑inflammatory effects for moderate pain in adults.

GNH USA supplies Nurofen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nurofen Plus combines an NSAID with an opioid, acting on inflammatory and nociceptive pathways to relieve moderate pain. - Dental pain: reduces pain and inflammation after dental procedures. - Musculoskeletal pain: alleviates pain from strains, sprains and backache. - Post‑operative pain: provides analgesia following minor surgery. - Dysmenorrhoea: eases menstrual cramps when other treatments are insufficient. - Acute injury pain: helps control pain from bruises or minor trauma.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Constipation: reduced bowel movements. - Dizziness: transient light‑headedness. - Drowsiness: increased sleepiness. - Abdominal pain: discomfort in the stomach area. - Dry mouth: reduced saliva production.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially with high opioid doses. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Gastrointestinal bleeding: vomiting blood or black stools. - Liver toxicity: elevated liver enzymes or jaundice. - Renal impairment: reduced kidney function. - Seizures: rare neurologic events.

Before using Nurofen Plus, consider the following safety measures. - Pregnancy: avoid unless clearly needed; discuss risks with a healthcare professional. - Breastfeeding: codeine may pass into milk; consult a doctor before use. - Liver disease: use with caution; monitor hepatic function. - Renal impairment: dose adjustment may be required. - Alcohol: limit intake as it can increase sedation and GI risk. - Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Nurofen Plus can interact with several medicines; awareness helps prevent adverse events.

Major Interactions (Avoid): - Other opioids: additive respiratory depression. - Benzodiazepines: enhanced sedation and CNS depression. - Anticoagulants (e.g., warfarin): increased risk of gastrointestinal bleeding. - MAO inhibitors: risk of severe hypotension. - CYP2D6 inhibitors: reduced conversion of codeine to morphine, decreasing analgesic effect.

Moderate Interactions (Monitor Closely): - SSRIs/SNRIs: potential for serotonin syndrome. - Diuretics: may reduce renal clearance of ibuprofen. - Antihypertensives: ibuprofen can blunt blood pressure control. - Antacids containing aluminum or magnesium: may affect absorption. - Lithium: ibuprofen can increase lithium levels.