Nurofen Plus (Ibuprofen, Codeine Phosphate Hemihydrate)

Ibuprofen and Codeine phosphate hemihydrate, the active ingredient in Nurofen Plus, is a NSAID; Opioid analgesic presented as an oral tablet for oral use. It provides pain relief and reduces fever in adults and adolescents when prescribed by a healthcare professional.

GNH USA supplies Nurofen Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global distribution, ensuring timely delivery and regulatory compliance across multiple markets.

Nurofen Plus combines ibuprofen and codeine to address pain and fever through anti‑inflammatory and opioid pathways.

Mild to moderate acute pain: provides effective analgesia Headache: reduces pain intensity Dental pain: alleviates postoperative discomfort Musculoskeletal pain: diminishes inflammation and soreness Fever: lowers elevated body temperature

Nurofen Plus may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects: - Nausea - Constipation - Dizziness - Drowsiness - Stomach upset - Headache

Serious or Rare Side Effects: - Respiratory depression - Severe allergic reactions (e.g., anaphylaxis) - Liver injury - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Seizures - Dependence or addiction potential

When prescribing or dispensing Nurofen Plus, consider the following precautions to ensure safe use.

Assess renal function: ibuprofen may impair kidney function, especially in dehydration. Monitor hepatic function: codeine metabolism can affect liver enzymes. Avoid in patients with respiratory disorders: risk of opioid‑induced respiratory depression. Use caution with alcohol: increased sedation and gastrointestinal irritation. Do not exceed prescribed dose: higher doses raise risk of toxicity and adverse events. Store at room temperature: keep in the original pack, protect from moisture.

Nurofen Plus can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid): - Other opioids: additive respiratory depression. - Benzodiazepines: enhanced sedation and CNS depression. - MAO inhibitors: risk of serotonin syndrome. - Alcohol: increased central nervous system depression.

Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): increased bleeding risk. - SSRIs or SNRIs: potential for serotonin syndrome. - Diuretics: reduced renal clearance of ibuprofen, affecting fluid balance.