Nurofen Orange, (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen Orange, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It treats pain, fever and inflammation in adults and children when taken as directed.

GNH USA supplies Nurofen Orange as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen is an NSAID that reduces pain, fever and inflammation by inhibiting prostaglandin synthesis.

- Pain: provides relief of mild to moderate pain such as headache, toothache or muscular discomfort. - Fever: lowers elevated body temperature associated with infections or inflammatory conditions. - Inflammation: alleviates swelling and discomfort in conditions like arthritis or minor injuries.

Common Side Effects: - Stomach upset or dyspepsia - Heartburn or acid reflux - Nausea or vomiting - Dizziness or light‑headedness - Headache - Skin rash or itching

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer formation - Severe allergic reactions including anaphylaxis - Kidney impairment or reduced renal function - Elevated liver enzymes or hepatic injury - Severe skin reactions such as Stevens‑Johnson syndrome - Blood disorders like thrombocytopenia

Before using ibuprofen, consider the following precautions: - Medical History Review: assess for existing ulcers, kidney disease, heart disease, asthma, or bleeding disorders. - Concomitant NSAIDs: avoid using with other NSAIDs to reduce gastrointestinal risk. - Alcohol Consumption: limit alcohol as it may increase stomach irritation and bleeding. - Dose Minimisation: use the lowest effective dose for the shortest duration needed. - Storage: Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen may interact with several medicines. Review the following groups:

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - ACE inhibitors (e.g., enalapril): may reduce renal function. - Lithium: ibuprofen can raise lithium serum levels. - Methotrexate: risk of heightened toxicity. - SSRIs (e.g., fluoxetine): additive bleeding risk.

Moderate Interactions (Monitor Closely): - Diuretics (e.g., furosemide): may lessen diuretic effectiveness. - Beta‑blockers (e.g., metoprolol): possible reduction in antihypertensive effect. - Caffeine: may increase nervous system side effects. - Alcohol: enhances gastrointestinal irritation. - Combined NSAID use: additive toxicity and ulcer risk.