Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a strength/form for oral use. It treats pain, inflammation and fever in adults and children as directed by a healthcare professional.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to relieve several common conditions. - Headache: reduces pain intensity and associated discomfort. - Dental pain: alleviates postoperative and dental procedure‑related pain. - Musculoskeletal pain: eases aches from strains, sprains and minor injuries. - Fever: lowers elevated body temperature in febrile states. - Menstrual discomfort: diminishes cramping and lower‑abdominal pain.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache unrelated to the treated condition. - Dizziness: occasional light‑headed sensation. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Hepatic injury: marked elevation of liver enzymes. - Renal impairment: acute kidney injury, especially with dehydration. - Anaphylaxis: rapid onset of airway swelling, hypotension and urticaria.

Before initiating ibuprofen therapy, consider the following safety measures. - Assess gastrointestinal risk: avoid in patients with active ulcers or severe dyspepsia. - Evaluate cardiovascular status: use cautiously in those with hypertension or heart disease. - Monitor renal function: contraindicated in severe renal impairment. - Review concomitant medications: avoid combined use with other NSAIDs or anticoagulants without supervision. - Pregnancy and lactation: limit use to the lowest effective duration and only when clearly needed. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ibuprofen may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: enhanced risk of renal insufficiency. - Lithium: increased serum lithium concentrations. - Methotrexate: reduced renal clearance leading to toxicity.