Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a non‑steroidal anti‑inflammatory drug presented as a suppository for rectal use. It treats mild to moderate pain, fever, and inflammatory conditions such as musculoskeletal discomfort and dysmenorrhea in appropriate patient groups.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to reduce inflammation and pain, making it useful for several common conditions.

- Mild to moderate pain: provides analgesia for headaches, dental pain, and postoperative discomfort. - Fever: lowers elevated body temperature associated with infections or inflammatory states. - Inflammatory conditions: alleviates swelling and pain in musculoskeletal disorders and dysmenorrhea.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Dyspepsia or stomach upset. - Nausea or mild vomiting. - Diarrhea or constipation. - Headache. - Dizziness. - Local irritation at the rectal site.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe allergic reactions such as anaphylaxis. - Renal impairment or acute kidney injury. - Hepatotoxicity. - Cardiovascular events like myocardial infarction. - Blood dyscrasias (e.g., thrombocytopenia).

Before using Nurofen suppositories, consider the following safety measures.

- Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding. - Use lowest effective dose: limit duration to the shortest period needed for symptom control. - Avoid in known hypersensitivity: discontinue if rash, swelling, or breathing difficulty occurs. - Caution in renal impairment: monitor kidney function in patients with existing renal disease. - Avoid concomitant anticoagulants unless medically indicated: increased bleeding risk. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may exacerbate renal impairment. - Lithium: ibuprofen can raise serum lithium concentrations, requiring monitoring.