GNH USA

Europe — EMA

Nurofen (Ibuprofen)

GNH USA supplies Nurofen (Ibuprofen), a NSAID for pain relief, fever reduction and inflammation.

Ibuprofen

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What is Ibuprofen?

Ibuprofen, the active ingredient in Nurofen, is a NSAID presented as a suppository for rectal use. It treats pain, fever and inflammation in adults and children as appropriate.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ibuprofen used for?

Ibuprofen, an NSAID that reduces prostaglandin‑mediated inflammation, is indicated for the following conditions:

Pain relief: alleviates mild to moderate pain such as musculoskeletal discomfort. Fever reduction: lowers elevated body temperature. Inflammation reduction: decreases swelling in injured tissues. Headache: provides relief from tension‑type and migraine‑associated pain. Dental pain: eases discomfort after dental procedures. Dysmenorrhea: reduces menstrual cramps.

What are the side effects of Ibuprofen?

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Stomach discomfort or dyspepsia - Nausea or vomiting - Diarrhea - Headache - Dizziness - Mild skin rash

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration - Severe allergic reactions such as anaphylaxis - Liver enzyme elevation or hepatitis - Kidney impairment or acute renal failure - Cardiovascular events like myocardial infarction or stroke - Blood disorders such as thrombocytopenia

What precautions apply to Ibuprofen?

When using Nurofen, consider the following precautions:

Assess gastrointestinal risk: avoid in patients with active ulcers or bleeding disorders. Monitor renal function: use cautiously in those with kidney disease or dehydration. Consider cardiovascular risk: limit use in patients with heart disease or hypertension. Avoid concurrent use with other NSAIDs or anticoagulants unless directed. Pregnancy and lactation: consult healthcare professional as safety is not established. Store at room temperature: keep in the original packaging, protect from moisture and heat.

What does Ibuprofen interact with?

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - ACE inhibitors or diuretics: may reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely): - SSRIs or SNRIs: elevated risk of GI bleeding. - Methotrexate: reduced clearance, possible toxicity.

Frequently asked questions

What is Nurofen used for?+
Nurofen is the brand name for ibuprofen formulated as a rectal suppository. It is used to relieve mild to moderate pain, reduce fever, and decrease inflammation associated with conditions such as headache, dental pain, musculoskeletal discomfort, and menstrual cramps. The suppository route offers an alternative when oral administration is not suitable.
How does ibuprofen work?+
Ibuprofen belongs to the non‑steroidal anti‑inflammatory drug class and works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of pain, fever, and inflammation. Reducing prostaglandin levels leads to analgesic, antipyretic, and anti‑inflammatory effects.
What is the usual dose of Nurofen?+
The specific dose of Nurofen suppository is determined by the prescribing healthcare professional based on the patient’s age, weight, condition being treated, and overall health status. The prescriber will select the appropriate strength and frequency, and patients should follow that guidance without deviation.
Is Nurofen safe during pregnancy or breastfeeding?+
The safety of ibuprofen suppositories in pregnancy and lactation has not been fully established. It is generally advised to avoid ibuprofen during the third trimester and to consult a healthcare provider before using it while pregnant or breastfeeding. The prescriber will weigh potential benefits against possible risks.
How do I order Nurofen from GNH USA?+
To place an order, visit the product page on gnh-usa.com and submit an enquiry with the required quantity of Nurofen suppositories. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.
How does Nurofen compare with other NSAIDs?+
Nurofen (ibuprofen) offers a well‑characterized safety and efficacy profile comparable to other non‑selective NSAIDs such as naproxen or diclofenac. Its rectal formulation provides an alternative route when oral intake is problematic, and its onset of action is similar to oral ibuprofen, though absorption may be slightly slower.
How should Nurofen be stored?+
Nurofen suppositories should be stored at room temperature, preferably below 25 °C, in the original packaging to protect them from moisture and heat. Keep the product out of reach of children and avoid exposure to direct sunlight or extreme temperatures, which could affect stability.
How is Nurofen administered?+
The suppository is inserted rectally, typically after a bowel movement and before lying down. The patient should wash hands, remove any protective wrapper, and gently push the suppository into the rectum using a finger or applicator, ensuring it is placed past the sphincter for optimal absorption.
What are the most serious risks associated with Nurofen?+
Serious adverse reactions, though uncommon, include gastrointestinal bleeding or ulceration, severe allergic responses such as anaphylaxis, kidney impairment, and cardiovascular events like myocardial infarction or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, blood in stool, swelling, or difficulty breathing.
Who should not use Nurofen?+
Nurofen should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, active gastrointestinal ulcers or bleeding, severe renal or hepatic impairment, uncontrolled hypertension, and in the third trimester of pregnancy. Additionally, patients taking anticoagulants, certain antihypertensives, or other NSAIDs should consult a healthcare professional before use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ibuprofen
Route
Rectal Use
Manufacturer
Reckitt Benckiser Healthcare, Lda.
Origin
EU

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