Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral formulation for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects, relieving mild to moderate pain, reducing fever, and decreasing inflammation associated with conditions such as arthritis, dental pain, and musculoskeletal injuries in adults and children when used as directed.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen, an NSAID, works on the prostaglandin pathway to manage pain, fever, and inflammation.

- Mild to moderate pain: provides relief from headaches, dental pain, menstrual cramps, and musculoskeletal discomfort. - Fever: reduces elevated body temperature in acute febrile states. - Inflammation: alleviates swelling and stiffness in arthritis and soft‑tissue injuries. - Arthritis: helps control joint pain and swelling in osteoarthritis and rheumatoid arthritis.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort. - Headache: mild to moderate intensity. - Dizziness or light‑headedness. - Skin rash: mild erythema or itching. - Elevated liver enzymes: transient increase in laboratory tests.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Acute renal impairment or failure. - Severe hypersensitivity reactions, including anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity: significant liver injury.

When using ibuprofen, consider the following precautions: - Assess renal function: avoid in patients with severe kidney disease. - Monitor gastrointestinal health: take with food to reduce irritation. - Avoid in known hypersensitivity to ibuprofen or other NSAIDs. - Use cautiously with anticoagulants: increased bleeding risk. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Ibuprofen may interact with several medicines. Review the following groups:

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may reduce renal function. - Lithium: ibuprofen can increase serum lithium concentrations. - Methotrexate: reduced clearance may raise toxicity levels.