Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It relieves pain, reduces fever, and eases inflammation in adults and children when appropriate. GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Ibuprofen works by inhibiting prostaglandin synthesis, providing analgesic, antipyretic, and anti‑inflammatory effects for common pain‑related conditions.

- Headache: relief of tension‑type or migraine‑associated pain. - Toothache: reduction of dental pain and associated inflammation. - Menstrual pain: alleviation of dysmenorrhea symptoms. - Musculoskeletal pain: easing of joint, muscle and back discomfort. - Fever: lowering elevated body temperature in acute febrile states.

Ibuprofen is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient mild headache. - Dizziness: occasional light‑headedness. - Rash: mild skin irritation or erythema. - Elevated blood pressure: modest increase in some patients.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Renal impairment: reduced kidney function or acute kidney injury. - Hepatotoxicity: elevated liver enzymes or hepatitis. - Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Cardiovascular events: increased risk of myocardial infarction or stroke in high‑risk individuals.

When using ibuprofen, consider the following safety measures.

- Assess renal function: avoid use in patients with severe kidney disease. - Monitor gastrointestinal risk: use with food or a proton‑pump inhibitor in those with ulcer history. - Evaluate cardiovascular status: exercise caution in patients with heart disease or hypertension. - Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without medical advice. - Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding. - Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy and renal function. - Diuretics: risk of decreased renal perfusion. - Lithium: elevated lithium levels. - Methotrexate: reduced clearance leading to toxicity.