Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It provides analgesic, antipyretic, and anti‑inflammatory effects for the relief of common pains and fever in adults and children when appropriate and can be used for short‑term management of mild to moderate discomfort.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable access to quality medicines across multiple regions.

Ibuprofen works by inhibiting cyclooxygenase enzymes, reducing prostaglandin production that contributes to pain and inflammation.

- Headache: reduces pain and discomfort associated with tension‑type headaches. - Toothache: alleviates dental pain and inflammation after procedures. - Menstrual pain: eases cramping and associated discomfort during menstruation. - Musculoskeletal pain: diminishes aches from strains, sprains, and arthritis. - Fever: lowers elevated body temperature in acute febrile states.

Adverse reactions to ibuprofen can vary from mild to severe and may affect different organ systems.

Common Side Effects: - Dyspepsia: upset stomach or indigestion. - Nausea: feeling of sickness or urge to vomit. - Headache: mild to moderate head pain. - Dizziness: transient light‑headedness. - Rash: mild skin irritation or redness.

Serious or Rare Side Effects: - Gastrointestinal bleeding: potentially life‑threatening hemorrhage. - Renal impairment: reduced kidney function or acute failure. - Severe allergic reaction: anaphylaxis with swelling, breathing difficulty, or hives.

When using ibuprofen, certain precautions should be observed to minimize risks.

- Assess renal function: avoid use in patients with severe kidney impairment. - Monitor gastrointestinal health: consider protective agents in those with ulcer history. - Check cardiovascular status: use cautiously in patients with heart disease. - Avoid use in late pregnancy: contraindicated in the third trimester. - Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Ibuprofen may interact with other medicines, altering their effectiveness or increasing toxicity.

Major Interactions (Avoid): - Aspirin: concurrent use can increase risk of gastrointestinal bleeding. - Anticoagulants (e.g., warfarin): may enhance anticoagulant effect and bleeding risk. - Selective serotonin reuptake inhibitors (SSRIs): combined use raises bleeding potential. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: may increase methotrexate toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may reduce antihypertensive effect. - Diuretics: can impair renal function when combined. - Beta‑blockers: possible reduction in blood pressure control.