Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral formulation for oral use. It is used to relieve mild to moderate pain, reduce fever, and lessen inflammation in a variety of conditions for adults and children as directed by a healthcare professional.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to reduce inflammation and pain through cyclo‑oxygenase inhibition, making it suitable for several common conditions.

- Headache: provides relief from tension‑type and mild migraine pain. - Fever: lowers elevated body temperature associated with infections or inflammatory states. - Musculoskeletal pain: eases discomfort from strains, sprains, arthritis and other inflammatory joint conditions.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching.

Serious or Rare Side Effects: - Gastrointestinal bleeding or perforation. - Severe allergic reactions such as anaphylaxis. - Acute kidney injury or worsening of chronic renal disease. - Hepatotoxicity presenting as elevated liver enzymes. - Increased risk of cardiovascular events, especially with long‑term use.

Before initiating ibuprofen therapy, consider the following safety measures.

- Assess renal function: avoid or adjust dose in patients with impaired kidney function. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Use with caution in asthma: monitor for bronchospasm. - Limit concurrent use with anticoagulants or other NSAIDs to reduce bleeding risk. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Ibuprofen can affect the activity of several other medicines; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Corticosteroids: synergistic risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely): - Diuretics and ACE inhibitors: may reduce renal perfusion. - Lithium: ibuprofen can raise serum lithium levels, requiring monitoring.