Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It provides analgesic, antipyretic and anti-inflammatory effects, helping to relieve mild to moderate pain, lower fever, and reduce swelling associated with conditions such as headache, dental pain, menstrual cramps, and musculoskeletal discomfort in both adults and children when appropriate.

GNH USA supplies Nurofen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality-assured product availability across diverse markets.

Ibuprofen, an NSAID, acts on inflammatory pathways to provide symptomatic relief.

- Mild to moderate pain: reduces pain intensity and improves daily activities. - Fever: lowers elevated body temperature. - Inflammatory conditions: diminishes swelling and tenderness. - Headache and dental pain: alleviates discomfort from cranial or oral sources. - Menstrual and musculoskeletal pain: eases cramps and joint or muscle soreness.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or heartburn. - Headache or dizziness. - Mild rash or itching. - Elevated blood pressure in some individuals.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Acute renal impairment or failure. - Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. - Hepatotoxicity in rare cases. - Cardiovascular events including myocardial infarction or stroke, especially with high‑dose or prolonged use.

Before using Nurofen, consider the following precautions: - Assess renal function: avoid in severe renal impairment. - Evaluate hypersensitivity: do not use if known allergy to ibuprofen or other NSAIDs. - Use the lowest effective dose and limit duration to reduce gastrointestinal risk. - Exercise caution in pregnancy: avoid use in the third trimester. - Review concomitant anticoagulant or antiplatelet therapy with a healthcare professional. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Ibuprofen may interact with several medicines. Monitor the following:

Major Interactions (Avoid): - Anticoagulants such as warfarin: increased bleeding risk. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Corticosteroids: heightened ulcer risk. - Lithium: possible increase in lithium levels. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: potential reduction in renal function. - Diuretics: may exacerbate renal impairment. - Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency. - Antihypertensives: possible attenuation of blood‑pressure‑lowering effect. - Oral hypoglycemics: may affect glucose control.