Nurofen (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen, is a non‑steroidal anti‑inflammatory drug presented as a tablet for oral use. It is used to relieve mild to moderate pain, reduce fever and treat inflammation in adults and children when appropriate.

GNH USA supplies Nurofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to reduce pain, fever and inflammation across several common conditions.

- Headache: provides relief by decreasing prostaglandin‑mediated pain signals. - Dental pain: eases post‑extraction or procedural discomfort. - Musculoskeletal pain: reduces inflammation and pain from sprains, strains and overuse. - Fever: lowers elevated body temperature in acute febrile states. - Dysmenorrhea: alleviates menstrual cramps by inhibiting uterine prostaglandin synthesis.

Adverse reactions may range from mild to severe, depending on individual susceptibility and exposure.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient tension‑type headache. - Dizziness: occasional light‑headedness. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: potentially life‑threatening hemorrhage. - Renal impairment: acute kidney injury, especially with dehydration. - Hepatic dysfunction: elevated transaminases or hepatitis. - Severe hypersensitivity: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Cardiovascular events: increased risk of myocardial infarction or stroke with prolonged high‑dose use.

Before using ibuprofen, consider the following safety measures.

- Assess renal function: avoid use in severe renal impairment. - Evaluate gastrointestinal risk: use cautiously in patients with a history of ulcers or bleeding. - Monitor cardiovascular status: limit use in individuals with uncontrolled hypertension or heart disease. - Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding. - Drug interactions: review concomitant medications for potential conflicts. - Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Ibuprofen may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: additive gastrointestinal toxicity. - Selective COX‑2 inhibitors: heightened cardiovascular risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: may diminish diuretic efficacy and affect kidney function. - Lithium: ibuprofen can raise serum lithium levels, requiring monitoring.