Nurofen Express (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen Express, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It provides analgesic, antipyretic and anti‑inflammatory effects for the temporary relief of mild to moderate pain, fever and inflammation in adults and children when used according to label instructions.

GNH USA supplies Nurofen Express as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and regulatory requirements to ensure product integrity.

Ibuprofen, an NSAID, works by reducing prostaglandin-mediated inflammation and is indicated for several common conditions.

- Headache: provides relief from tension‑type and mild migraine headaches. - Dental pain: reduces discomfort associated with toothaches and post‑extraction soreness. - Fever: lowers elevated body temperature caused by infection or other febrile illnesses. - Musculoskeletal pain: eases aches from minor sprains, strains or arthritis flare‑ups.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache unrelated to the condition being treated. - Dizziness: occasional light‑headedness or vertigo. - Rash: mild skin erythema or itching.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: severe stomach or intestinal bleeding. - Renal impairment: reduced kidney function or acute renal failure. - Severe allergic reactions: anaphylaxis, angioedema or Stevens‑Johnson syndrome.

When using ibuprofen tablets, consider the following precautions to minimize risk. - Assess medical history: evaluate for existing gastrointestinal ulcers, bleeding disorders or cardiovascular disease. - Use lowest effective dose: limit duration and dose to the minimum needed for symptom control. - Avoid in late pregnancy: contraindicated during the third trimester due to fetal risks. - Monitor renal function: patients with kidney disease should be observed for changes in creatinine. - Caution with other NSAIDs: concurrent use may increase adverse effect risk. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can interact with other medicines, altering their effectiveness or safety profile.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential. - ACE inhibitors or ARBs: may reduce antihypertensive effect and impair kidney function. - Lithium: ibuprofen can raise lithium serum concentrations.

Moderate Interactions (Monitor Closely): - Diuretics: possible reduction in diuretic efficacy and renal perfusion. - Methotrexate: decreased clearance leading to toxicity. - Corticosteroids: additive risk of gastrointestinal ulceration. - Antihypertensives (beta‑blockers): may blunt blood pressure control. - Oral hypoglycemics: potential alteration of blood glucose levels.