Nurofen Duo (Ibuprofen, Paracetamol)

Ibuprofen, the active ingredient in Nurofen Duo, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a combined oral tablet for systemic use. It treats mild to moderate pain and reduces fever, often in conjunction with paracetamol for enhanced effect. GNH USA supplies Nurofen Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nurofen Duo combines ibuprofen and paracetamol to address pain and inflammation pathways in several common conditions. - Headache: provides rapid relief of tension‑type and mild migraine symptoms. - Dental pain: reduces postoperative discomfort after extractions or procedures. - Musculoskeletal pain: eases aches from sprains, strains and minor arthritis. - Fever: lowers elevated body temperature in adults. - Menstrual cramps: alleviates dysmenorrhoeic pain during periods.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Gastrointestinal discomfort such as nausea or dyspepsia. - Headache or dizziness. - Mild skin rash or itching. - Elevated liver enzymes (asymptomatic laboratory finding).

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe skin reactions like Stevens‑Johnson syndrome. - Hepatotoxicity, particularly with overdose or chronic use. - Renal impairment or acute kidney injury. - Anaphylaxis or severe hypersensitivity reactions.

Before initiating therapy, consider the following safety measures: - Assess renal function: patients with chronic kidney disease may require dose adjustment. - Evaluate hepatic status: avoid use in severe liver impairment. - Review cardiovascular risk: NSAIDs can increase blood pressure and fluid retention. - Check for gastrointestinal history: prior ulcers or bleeding raise risk of GI complications. - Avoid concurrent use with other NSAIDs or high‑dose paracetamol. - Store at ambient temperature: keep tablets in the original container, protect from moisture and heat.

Nurofen Duo may interact with several drug classes; monitoring and avoidance strategies are recommended.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - High‑dose aspirin or other NSAIDs: additive gastrointestinal toxicity. - Certain antihypertensives (ACE inhibitors, ARBs, diuretics): may reduce renal perfusion.

Moderate Interactions (Monitor Closely): - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: reduced clearance may increase toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk. - Alcohol: potentiates liver toxicity and gastric irritation.