Nurofen 400 Female (Ibuprofen Lysine)

Ibuprofen, the active ingredient in Nurofen 400 Female, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a 400 mg oral tablet for short‑term pain and fever relief in adults. It is commonly used to treat mild to moderate pain, inflammation and fever in women who prefer a formulation marketed toward female consumers.

GNH USA supplies Nurofen 400 Female as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen lysine acts systemically to reduce pain, inflammation and fever across several common conditions.

- Headache: provides relief from tension‑type and mild migraine headaches. - Dental pain: alleviates pain following dental procedures or toothache. - Musculoskeletal pain: reduces discomfort from sprains, strains and minor joint aches. - Menstrual discomfort: eases cramps and associated lower‑abdominal pain. - Fever: helps lower elevated body temperature in acute febrile episodes.

Adverse reactions to ibuprofen lysine can vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: mild nausea, dyspepsia or heartburn. - Headache: transient headache unrelated to the condition being treated. - Dizziness: occasional light‑headed sensation. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic or diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe allergic reactions: anaphylaxis, angio‑edema. - Hepatic injury: marked elevation of liver enzymes. - Renal impairment: acute kidney injury, especially with dehydration. - Cardiovascular events: increased risk of myocardial infarction or stroke.

When considering ibuprofen lysine therapy, several safety measures are recommended.

- Assess gastrointestinal risk: avoid in patients with active ulcers or severe dyspepsia. - Evaluate cardiovascular status: use cautiously in those with hypertension or heart disease. - Monitor renal function: contraindicated in severe renal impairment. - Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without supervision. - Pregnancy and lactation: limit use to the lowest effective duration and only if benefits outweigh risks. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ibuprofen lysine may alter the efficacy or safety profile of several co‑administered medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: enhanced risk of renal impairment. - Lithium: increased serum lithium concentrations. - Methotrexate: reduced renal clearance leading to toxicity.