Nurofen 400 (Ibuprofen)

Ibuprofen, the active ingredient in Nurofen 400, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a 400 mg tablet for oral use. It treats pain, fever and inflammation in adults and adolescents.

GNH USA supplies Nurofen 400 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen, an NSAID that reduces prostaglandin synthesis, is indicated for several common pain and inflammatory conditions.

Headache: relief of mild to moderate headache symptoms. Dental pain: reduction of pain following dental procedures. Musculoskeletal pain: alleviation of aches associated with strains, sprains and arthritis. Menstrual pain: easing of dysmenorrhea. Fever: lowering elevated body temperature. Osteoarthritis: mitigation of joint inflammation and stiffness.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or heartburn. - Dizziness or mild headache. - Mild skin rash or itching.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Acute renal impairment, especially in dehydrated patients. - Severe allergic reactions such as anaphylaxis. - Elevated liver enzymes or hepatitis. - Rare dermatologic disorders like Stevens‑Johnson syndrome.

Before using Nurofen 400, consider the following precautions: - Assess renal function: avoid in severe renal impairment. - Avoid in known hypersensitivity to ibuprofen or other NSAIDs. - Use with caution in patients with cardiovascular disease. - Limit alcohol consumption: may increase gastrointestinal risk. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at ambient temperature: keep in the original pack, protect from moisture.

Ibuprofen may interact with several medicines; review the following groups: Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - High‑dose aspirin: enhanced renal toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function. - Diuretics: risk of electrolyte imbalance. - Lithium: ibuprofen can raise serum lithium levels.