Nureflex (Ibuprofen)

Ibuprofen, the active ingredient in Nureflex, is a Non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for systemic use. It provides analgesic, antipyretic and anti‑inflammatory effects for adults and children when prescribed by a healthcare professional.

GNH USA supplies Nureflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to reduce pain, fever and inflammation across a range of common conditions.

- Headache: alleviates mild to moderate headache pain. - Dental pain: reduces discomfort following dental procedures. - Musculoskeletal pain: eases pain and swelling associated with sprains, strains and minor injuries. - Fever: lowers elevated body temperature in acute febrile states. - Osteoarthritis and rheumatoid arthritis: diminishes joint pain and stiffness, improving mobility.

Adverse reactions may occur with ibuprofen use and are categorised by frequency and severity.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache unrelated to the condition being treated. - Dizziness: occasional light‑headedness or vertigo. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic or diastolic pressure. - Fluid retention: mild peripheral oedema.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration. - Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Hepatic injury: marked elevation of liver enzymes. - Renal impairment: acute kidney injury, especially with dehydration. - Cardiovascular events: increased risk of myocardial infarction or stroke with long‑term high‑dose use. - Hematologic abnormalities: thrombocytopenia or leukopenia.

Before using ibuprofen, consider the following safety measures.

- Assess renal function: avoid use in patients with severe renal impairment. - Evaluate cardiovascular risk: use cautiously in individuals with hypertension, heart disease or stroke history. - Monitor gastrointestinal health: avoid in patients with active peptic ulcer disease or a history of GI bleeding. - Check for hypersensitivity: discontinue if signs of allergic reaction appear. - Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without medical guidance. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects. - Lithium: ibuprofen may raise lithium serum concentrations. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: potential reduction in renal function. - Diuretics: may enhance renal adverse effects. - SSRIs or SNRIs: increased bleeding tendency. - Corticosteroids: elevated risk of gastrointestinal ulceration. - Antihypertensives: possible attenuation of blood pressure‑lowering effect.