GNH USA

Europe — EMA

Numeta G16e

GNH USA supplies Numeta G16e (amino acid solution), a nutritional supplement for parenteral nutrition and amino acid supplementation.

Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio

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What is Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio?

Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine and Methionine, the active ingredients in Numeta G16e, are an amino acid solution presented as an intravenous solution for intravenous use. It provides essential amino acids to patients requiring parenteral nutrition when oral or enteral feeding is not possible.

GNH USA supplies Numeta G16e as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The product meets EU quality standards and is intended for clinical use in acute‑care settings.

What is Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio used for?

Numeta G16e delivers a balanced mixture of essential amino acids for patients who cannot receive nutrition through the gastrointestinal tract. - Parenteral nutrition: supplies the amino acids needed for protein synthesis in patients dependent on intravenous feeding. - Critical‑care nutrition: helps meet the heightened metabolic demands of ICU patients. - Pre‑ and post‑operative support: provides amino acid substrates to aid recovery after major surgery.

What are the side effects of Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio?

Numeta G16e may be associated with infusion‑related and metabolic reactions.

Common Side Effects: - Hyperglycemia: elevated blood glucose levels during infusion. - Electrolyte imbalance: changes in potassium, sodium or calcium concentrations. - Infusion site irritation: redness, pain or phlebitis at the catheter site. - Nausea or mild vomiting. - Metabolic alkalosis: shift in acid‑base balance. - Mild hepatic enzyme elevation.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate intervention. - Severe metabolic acidosis: rapid drop in blood pH. - Renal impairment: worsening kidney function in susceptible patients. - Hepatic dysfunction: significant liver enzyme rise or cholestasis. - Thrombophlebitis: clot formation with vein inflammation. - Severe electrolyte disturbances: life‑threatening hyper‑ or hypo‑kalemia.

What precautions apply to Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio?

When using Numeta G16e, clinicians should observe several safety measures. - Renal function assessment: evaluate creatinine clearance before and during therapy. - Electrolyte monitoring: check serum potassium, sodium, calcium and magnesium regularly. - Blood glucose control: monitor glucose levels, especially in diabetic patients. - Hepatic status review: adjust dosing if liver enzymes are markedly elevated. - Aseptic technique: ensure sterile handling of the IV solution to prevent contamination. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio interact with?

Numeta G16e can interact with other intravenous agents and systemic medications.

Major Interactions (Avoid): - High‑dose potassium chloride: risk of severe hyperkalemia when combined. - Calcium gluconate: potential precipitation of calcium‑phosphate complexes. - Large amounts of vitamin C: may increase oxalate load and renal stone risk.

Moderate Interactions (Monitor Closely): - Loop diuretics: may exacerbate electrolyte shifts during amino acid infusion. - Insulin therapy: concurrent use may require tighter glucose monitoring. - Other parenteral nutrition components: adjust total nutrient load to avoid over‑feeding.

Frequently asked questions

What is Numeta G16e used for?+
Numeta G16e is an intravenous amino acid solution used to provide essential amino acids to patients who cannot receive nutrition through the gastrointestinal tract. It is indicated for parenteral nutrition, critical‑care support, and pre‑ or post‑operative amino acid supplementation in hospital settings.
How does the amino acid mixture in Numeta G16e work?+
The mixture delivers a balanced profile of essential amino acids directly into the bloodstream, bypassing the gut. These amino acids serve as building blocks for protein synthesis, support nitrogen balance, and help maintain metabolic functions in patients who are unable to ingest food or enteral formulas.
What is the usual dose of Numeta G16e?+
The dose of Numeta G16e is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, renal and hepatic function, and overall nutritional goals. Healthcare professionals calculate the infusion rate and total daily amount according to established parenteral nutrition protocols.
Is Numeta G16e safe to use during pregnancy or breastfeeding?+
Safety data for Numeta G16e in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order Numeta G16e from GNH USA?+
To order Numeta G16e, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.
How does Numeta G16e compare with other parenteral amino acid solutions?+
Numeta G16e offers a comprehensive blend of nine essential amino acids formulated for balanced protein synthesis. Compared with some older formulations that may lack certain amino acids or have different osmolarities, Numeta G16e is designed to meet EU quality standards and provide a stable, isotonic solution suitable for a wide range of clinical nutrition protocols.
What are the storage and handling requirements for Numeta G16e?+
Numeta G16e must be stored refrigerated at 2‑8 °C. Keep the container in its original packaging, protect it from light, and avoid freezing or shaking the solution. Before use, inspect for particulate matter or discoloration and follow aseptic techniques during preparation.
How is Numeta G16e administered?+
Numeta G16e is administered intravenously, typically via a central or peripheral venous catheter. The infusion rate is calculated by the prescribing clinician and the solution is delivered using an infusion pump or gravity set, following sterile preparation and monitoring guidelines.
What are the most serious risks associated with Numeta G16e?+
Serious risks include anaphylactic reactions, severe electrolyte disturbances (especially hyper‑ or hypo‑kalemia), metabolic acidosis or alkalosis, renal impairment, and hepatic dysfunction. Prompt recognition and management of these events are essential, and patients should be closely monitored during and after infusion.
Who should not receive Numeta G16e?+
Numeta G16e should be avoided in patients with known hypersensitivity to any of its amino acid components, in those with uncontrolled severe electrolyte abnormalities, or in individuals with severe hepatic or renal failure where the risk of accumulation outweighs potential benefit. Clinical judgment is required for each case.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Valine, Ornithine Hydrochloride, Alanine, Arginine, Cysteine, Histidine, Isoleucine, Leucine, Methio
Route
Intravenous Use
Manufacturer
Baxter Holding B.V.
Origin
EU